艾地苯醌的简便合成  

Simple Synthesis of Idebenone

作　　者：杨超文[1] 雷泽[1] 付正启[1] 木晓云[1] 严云南[1] 朱洪友[1] 

机构地区：[1]云南大学化学科学与工程学院,昆明650091

出　　处：《高等学校化学学报》2007年第6期1101-1103,共3页Chemical Journal of Chinese Universities

基　　金：云南省自然科学基金(批准号:2003C009M);云南省人才基金(批准号:2000YP25)资助

摘　　要：Idebenone is a synthetic analog of coenzyme Q10.It has clinical applications in many central ner-vous system degenerative diseases associated with oxidative stress,such as Parkinson’s and Alzheimer’s diseases,and especially in the therapy of Friedreich’s ataxia.According to the established method of synthesizing the quinone using 3,4-cyclopendadiene as auxiliary reagent by Hamamura,the target compound with a good productivity was obtained firstly by using the alkylation reaction of quinone as the key step and coenzyme Q0 and 1,10-decanediol as the first materials of main body and side chain,respectively,the reactions proceed smoothly under mild conditions to give the expected proucts in good yields.Contrast to the original method,this method is more simple,efficient and practical.Idebenone is a synthetic analog of coenzyme Q10.It has clinical applications in many central ner-vous system degenerative diseases associated with oxidative stress, such as Parkinson＇s and Alzheimer＇s disea-ses, and especially in the therapy of Friedreich＇s ataxia. According to the established method of synthesizing the quinone using 3,4-cyclopendadiene as auxiliary reagent by Hamamura, the target compound with a good productivity was obtained firstly by using the alkylation reaction of quinone as the key step and coenzyme Q0 and 1,10-decanediol as the first materials of main body and side chain, respectively, the reactions proceed smoothly under mild conditions to give the expected proucts in good yields. Contrast to the original method, this method is more simple, efficient and practical.

关 键 词：艾地苯醌 癸二醇 辅酶Qo 环戊二烯 

分 类 号：O62[理学—有机化学]