24p3-24p3受体系统:一种新的铁转运途径  

24p3-24p3 Receptor System: A New Pathway of Iron Transport

作　　者：赵颂民[1] 石振华[1] 段相林[1] 常彦忠[1] 

机构地区：[1]河北师范大学,河北省动物生理生化与分子生物学重点实验室,石家庄050016

出　　处：《生物化学与生物物理进展》2007年第6期557-561,共5页Progress In Biochemistry and Biophysics

基　　金：国家自然科学基金(30570957);河北省自然科学基金(C2006000152)资助项目~~

摘　　要：小鼠24p3是脂质运载蛋白lipocalin家族的成员之一,可在白介素3(interleukin-3,IL-3)缺乏时诱导细胞发生凋亡,并参与细胞的铁转运过程.最近,Devireddy等又成功克隆到了24p3的细胞表面受体(24p3 receptor,24p3R),进一步确定了24p3-24p3R这一新的铁转运途径.该途径的发现不仅增加了对铁转运理论新的认识,更重要的是,这一发现为铁代谢调控细胞凋亡理论的建立奠定了基础.The 24p3 of mouse is a member of lipocalin family and it has been implicated in iron transport and apoptosis due to interleukin-3（IL-3） deprivation. Devireddy and colleagues cloned the receptor of 24p3 and further confirmed that the pathway of 24p3-24p3R is a new iron transport approach in Dec 2005. A link between iron internalization mediated by 24p3R and regulation of apoptosis was suggested.

关 键 词：24p3-24p3受体系统 铁转运 细胞凋亡 

分 类 号：Q493.7[生物学—生理学]