血浆sES、MMP-9和TIMP-1与冠状动脉扩张的关系  

Relationship between sES、MMP-9 and coronary artery dilation

作　　者：陈连凤[1] 姚义安[1] 张抒扬[1] 吴炜[1] 戴宇翔[1] 

机构地区：[1]中国医学科学院中国协和医科大学北京协和医院心内科,北京100730

出　　处：《基础医学与临床》2007年第6期625-628,共4页Basic and Clinical Medicine

基　　金：国家自然科学基金(30470726)

摘　　要：目的探讨炎症因子可溶性E选择素(sES)、基质金属蛋白酶-9(MMP9)、基质金属蛋白酶抑制物-1(TIMP-1)与冠脉扩张的关系及其临床意义。方法选择我院行冠脉造影的部分患者,根据冠造结果分三组,其中I组为冠状动脉扩张,共11例;冠状动脉粥样硬化为II组,共35例;造影正常者为III组,共24例。用ELISA法检测血浆MMP-9及其抑制物TIMP1水平。结果sES及MMP-9水平在冠脉扩张组明显高于冠脉粥样硬化组及冠脉造影正常组(P<0.05)。血浆TIMP1水平在三组中相近。结论sES、MMP-9/TIMP-1与冠脉扩张相关,它们可能参与了冠脉扩张的发生,在冠脉疾病的进展中起重要作用。Objective To investigate the relationship between inflammatory factors, coronary artery dilation, and their clinical significance. Methods The cases undergone coronary angiography in our hospital last year were collected and divided into three groups： the first one included 11 patients whose angiography showed coronary artery dilation, the second group included 35 eases of atheroselerosis, and the third includes 24 eases with normal angiography, sES, MMP9 and TIMP1 were measured by ELISA method. Results Patients with coronary artery dilation were found to have significantly higher sES and MMP-9 level in comparison with atheroselerosis group and normal group[ （ 153.7 ± 152. 7） ng/L, （90. 1 ±54. 2）ng/L, （76. 5 ±37.2） ng/L, respectively] （P 〈0. 05） ）, but there was no significant difference of TIMP-1 among three groups [ （ 8106± 1218） ng/L, （ 8203 ± 834） ng/L, （ 8433 ± 867） ng/L]. Conclusion sES and MMP-9 are associated with coronary artery dilation, they potentially attribute to the coronary artery dilation and play an important roles in the coronary artery pathogenesis.

关 键 词：SES MMP-9 TIMP-1 冠状动脉扩张 冠状动脉粥样硬化 

分 类 号：R543[医药卫生—心血管疾病]