大鼠下丘脑外侧区注射去甲肾上腺素抑制小肠肌电活动  

Injection of noradrenaline to lateral hypothalamus area (LHA) inhibits small intestine myoelectric activity in rats

作　　者：宋婷婷[1] 杨德治[2] 魏义全[2] 寻庆英[2] 

机构地区：[1]江苏先声药物研究院,江苏南京210042 [2]东南大学基础医学院,江苏南京210009

出　　处：《基础医学与临床》2007年第6期648-651,共4页Basic and Clinical Medicine

基　　金：铁道部科技基金(6747600062)

摘　　要：目的研究大鼠下丘脑外侧区(LHA)的去甲肾上腺素(NE)对小肠运动的影响。方法采用消化道腔外电极记录法及中枢立体定位术,观察在LHA分别注射生理盐水、NE、酚妥拉明(PHEN)、PHEN+NE、普萘洛尔+NE(PP+NE)对大鼠小肠消化间期移行性复合肌电(MMC)周期时程、活动期/周期比例、活动期每分钟快波数的影响。结果LHA内注入NE后第1、2个MMC周期时程明显延长、活动期占周期比例缩小、活动期每分钟快波数减少;这种作用被酚妥拉明阻断,但不能被普萘洛尔阻断;LHA内单独注入酚妥拉明后第1、2个MMC周期中活动期占周期比例延长。结论下丘脑外侧区的NE对小肠肌电活动有抑制性调节作用,这种作用可能是通过α受体介导的。下丘脑外侧区的α受体可能参与了小肠电活动的抑制。Objective To study the influence of Noradrenergic systems in Lateral Hypothalamus Area （LHA） on small intestine moving. Methods The effect of noradrenalin,noradrenalin ＋ phentolamine,noradrenalin ＋ propolol, phentolamine on small intestines electro-activity of rats was detected by external alimentary canal electrodes and central nervous system stereo-configuration technology. Results After injecting 2 g/L noradrenaline （NE） the cyclic period of MMC extended, the ratio of the active time to the cyclic period and the number of the fast wave within the active time per minute reduced. NE inhibited the electro-activity of small intestine of rats, and the average effective time was （36. 86 ±7.39）min. Hence injecting 5 g/L PE alone to LHA raised the ratio of the MMC active time to the cyclic period. Phentolamine presented a slight excitability on the electro-activity of small intestine of rats. Conclusion The NE in LHA showed the inhibitive was introduced small intestines through a acceptor,The reacceptor in LHA myoelectric activity on small intestines, and this effect may function in the inhibition of the electro-activity in small intestines.

关 键 词：下丘脑外侧区 去甲肾上腺素 小肠 移行性综合肌电 Α受体 

分 类 号：R33[医药卫生—人体生理学]