MUC5AC黏蛋白在哮喘大鼠肺组织的表达及红霉素的抗炎机制探讨  

Expression of Mucin MUC5AC in Rats with Asthma and Mechanisms of Anti-inflammatory Effects of Erythromycin

作　　者：王同生[1] 娄源杰[1] 毛毅敏[1] 孙玉霞[1] 

机构地区：[1]河南科技大学第一附属医院,河南洛阳471003

出　　处：《河南科技大学学报（医学版）》2007年第1期11-13,共3页Journal of Henan University of Science & Technology:Medical Science

摘　　要：目的研究哮喘大鼠肺组织MUC5AC黏蛋白的分布及红霉素对其影响。方法36只清洁级SD大鼠随机分成对照组、哮喘组、和红霉素治疗组,采用免疫组化SP法和计算机图象分析检测肺组织中MUC5AC黏蛋白的分布。结果哮喘组MUC5AC黏蛋白表达(2.4167±0.6686)较对照组(0.5833±0.7930)明显增加,红霉素治疗组(1.1667±0.9374)降低,和哮喘组相比有统计学意义。结论反复抗原刺激引起气道过敏性炎症,导致气道黏蛋白的大量产生,加重哮喘气道炎症和气道阻塞,红霉素可下调MUC5AC黏蛋白,对气道黏蛋白高分泌有明显的治疗作用。Objective To investigate the distribution of protein MUC5AC in the lungs of asthmatic SD rats and the effects of erythromycin. Methods Thirty-six SD rats were randomly divided into control group, asthmatic group, and erythromycin-treated group, and each immunohistochemical SP method and computer image analysis were used in this study. Results Protein MUC, SAC （2. 4167 ± 0. 6686 ） in asthmatic group were significantly higher than those in control group （0. 5833 ± 0. 7930.） and reduced （ 1. 1667 ± 0.9374） after treatment with erythromycin. Conclusion Repeated antigen challenges,which cause the allergic inflammation of airways, may result in mucin hypersecretion; this may be involved in the persistence and exacerbation of airway inflammation and obstruction in asthma. Erythromyein substantially downregulates protein MUC5AC, which may have potential therapeutic role in mucin overproduction of airway.

关 键 词：红霉素 支气管哮喘 黏蛋白 MUC5AC 

分 类 号：R563[医药卫生—呼吸系统]