调脂治疗对不稳定型心绞痛患者血清IL-6、hsCRP、sCD40L的影响  

The Effects of Antihyperlipemia Therapy on IL-6, hsCRP and sCD40L Serum Level in Patients with Unstable Angina

作　　者：林开敏[1] 李卫华[1] 戴淑惠[2] 

机构地区：[1]福建医科大学附属厦门第一医院心内科,厦门361003 [2]福建医科大学附属厦门第一医院检验科,厦门361003

出　　处：《福建医科大学学报》2007年第3期239-241,共3页Journal of Fujian Medical University

摘　　要：目的探讨调脂治疗在冠心病治疗中的作用机制。方法选取不稳定型心绞痛合并高脂血症患者52例,随机分为研究组和对照组,研究组在对照组常规治疗的基础上加用阿托伐他汀,治疗前后分别测定白细胞介素-6(IL-6)、超敏C-反应蛋白(hsCRP)和可溶性CD40L(sCD40L)和血脂水平,观察阿托伐他汀对不稳定型心绞痛合并高脂血症患者血清中IL-6、hsCRP、sCD40L水平的影响。结果治疗5d后,研究组患者血清中IL-6由(6.63±1.44)mg/L降至(3.03±1.45)mg/L,hsCRP由(9.95±3.62)mg/L降至(5.25±3.12)mg/L,sCD40L由(3.82±1.55)ng/mL降至(2.82±1.55)ng/mL,差别有统计学意义(P<0.05)。结论不稳定型心绞痛合并高脂血症患者使用他汀类药物早期就具有抗炎作用;尽早使用可使患者获益更大。Objective To explore the effect of antihyperlipemia on interleukin-6（IL-6）, high-sensitively C-reactive protein（hsCRP） and sCD40L serum level in unstable angina patients with hyperlipemia. Methods 52 unstable angina（UA） patients with hyperlipemia were randomized to either normal therapy （n1 =26, control group） or atorvastatin therapy in 10 mg/d（n2 =26, therapeutic group）, in which 11.-6, hsCRP and sCD40L serum level were investigate. Results After 5 days of treatment, the IL-6 level decreased from（6.63±1.44） to （3.03±1.45） mg/L（P〈0.05）, the hsCRP level decreased from（9.95±3.62） to （5.25±3.12） mg/L（P〈0.05）, the sCD40L level decreased from（3.82±1.55） to （2.82±1.55）ng/ml.（P〈0.05）. Conclusion The antiinflammatory effect of statin was demonstrated in the early stage in patients with UA. The earlier use of statin, the more advantage found.

关 键 词：心绞痛 不稳定型 C-反应蛋白 白细胞介素-6 CD40配体 降血脂类 

分 类 号：R541.4[医药卫生—心血管疾病]