手术创伤应激患者血清Cor与ACTH含量的变化  

Changes of Serum Contents of Cortisol and ACTH in Patients After Operation

作　　者：朱良红[1] 张新路[2] 程光华[2] 

机构地区：[1]皖南医学院弋矶山医院急诊外科,241001 [2]皖南医学院弋矶山医院核医学科,241001

出　　处：《放射免疫学杂志》2007年第3期210-212,共3页Journal of Radioimmanology

摘　　要：目的:观察手术创伤前后患者血清皮质醇(cortisol,Cor)与促肾上腺皮质激素(adrenocorticotrophic hormone,ACTH)水平的变化。方法:对45例经受Ⅲ类手术组(30例)、Ⅳ类手术组(15例)患者术前、术后第1d及第3d血清Cor与ACTHRIA。结果:术后第1dⅢ类、Ⅳ类手术组血清Cor与ACTH含量较术前均显著升高,且Ⅳ类手术组显著高于Ⅲ类手术组。术后第3d两组血清Cor含量均显著降低且低于术前,而两组ACTH含量显著高于术前及术后第1d;术后第3d,两组之间血清Cor与ACTH含量比较无统计学意义。结论:手术创伤早期可使血清Cor与ACTH含量升高,Cor的升高程度可能与手术创伤程度有关。Objective To study the changes of serum contents of cortisol and ACTH after operation. Methods Serum cortisol and ACTH levels were measured with RIA both before and ld, 3d post - operatively in 30 patients after Grade Ⅲ operation and 15 patients after Grade Ⅳ operation. Results On the first post- operative day, the serum cortisol and ACTH levels in both groups of patents were significantly higher than their respective pre - operative levels. Levels in Grade Ⅳ group were significantly higher than those in Grade Ⅲ group. On the third post - operative day, the serum cortisol levels dropped markedly and were lower than their respective pre - operative levels. However, the serum ACTH levels continued to rise in both groups and were significantly higher than the respective levels pre - operatively as well as those on dl. The ACTH levels in the two groups were not significantly different on d3. Conclusion Serum eortisol and ACTH levels increased in the early post - operative phase and the degree of increase of cortisol was correlated with the magnitude of the operation.

关 键 词：皮质醇 促肾上腺皮质激素 手术创伤 应激 

分 类 号：R614.42[医药卫生—麻醉学]