氟伐他丁对ACS患者CRP及sICAM-1、sVCAM-1的影响  

Effect of Fluvastatin on Serum CRP, SLCAM-1 and SVCAM-1 Contents in Patients with Acute Coronary Syndrome

作　　者：孙黎明[1] 周哲[2] 周新华[1] 王怡练[1] 左逸夫[1] 滕士阶[3] 

机构地区：[1]连云港市第二人民医院心内科,222023 [2]连云港市第二人民医院妇产科,222023 [3]连云港市第二人民医院检验科,222023

出　　处：《放射免疫学杂志》2007年第3期280-281,共2页Journal of Radioimmanology

基　　金：连云港市125工程医学重点人才资助项目

摘　　要：Objective To study the effect of fluvastatin on changes of serum C-reactive protein(CRP) and soluable intercellular adhesion molecule-1(sICAM-1),soluabe vas-cular cell adhesion molecule-1(sVCAM-1) contents in patients with acute coronary syndrome(ACS). Methods 109 patients with ACS were randomly divided into fluvastatin-treated group(55 cases) and conventional therapy group (54 cases). The contents of serum CRP (with immunoturbidity method), sICAM-1,sVCAM-1 (with ELISA) were measured both before and after treatment for 8 weeks with fluvastat in in these cardiac patients as well as in 50 controls. Results ① Befor treatment, the levels of serum CRP, sICAM-1, sVCAM-1 were significantly higher in the patients with ACS than controls(P<0.01). ②After treatment,the levels of serum CRP, sICAM-1,sVCAM-1 in patients with fluvastatin decreased significantly(P<0.01), but the levels were not much changed in the conventional therapy group. Conclusion Fluvastatin can decrease inflammation and cell adhesion in patients with ACS .Objective To study the effect of fluvastatin on changes of serum C - reactive protein（CRP） and soluable intercellular adhesion molecule - 1 （ sICAM - 1 ）, soluabe vas - cular cell adhesion molecule - 1 （ sVCAM - 1 ） contents in patients with acute coronary syndrome（ACS）. Methods 109 patients with ACS were randomly divided into fluvastatin - treated group（55 cases） and conventional therapy group （54 cases ）. The contents of serum CRP （ with immunoturbidity method）, sICAM - 1, sVCAM - 1 （with ELISA） were measured both before and after treatment for 8 weeks with fluvastat in in these cardiac patients as well as in 50 controls. Results ① Befor treatment, the levels of serum CRP, sICAM - 1, sVCAM - 1 were significantly higher in the patients with ACS than controls（P 〈0.01 ）. ②After treatment,the levels of serum CRP, sICAM - 1 ,sVCAM - 1 in patients with fluvastatin decreased significantly（P 〈0.01）, but the levels were not much changed in the conventional therapy group. Conclusion Fluvastatin can decrease inflammation and cell adhesion in patients with ACS .

关 键 词：急性冠状动脉综合征 氟伐他丁 C-反应蛋白 细胞黏附分子 

分 类 号：R541.4[医药卫生—心血管疾病]