丙泊酚对兔肝脏缺血后再灌注损伤的保护作用  

Protective Effects of Propofol on Liver Ischemia Reperfusion Injury in Rabbits

作　　者：杜津[1] 刘宗民[1] 李文硕[2] 贾凤亭[1] 侯伯轩[1] 任广理[1] 

机构地区：[1]解放军第254医院麻醉科,天津300142 [2]天津医科大学总医院麻醉科,天津300052

出　　处：《临床军医杂志》2007年第3期337-339,共3页Clinical Journal of Medical Officers

摘　　要：目的探讨丙泊酚对兔肝脏缺血后再灌注损伤的影响。方法将实验兔随机分为拟手术组(S组),肝脏缺血后再灌注组(IR组),及微量泵连续静脉输注丙泊酚[10mg/(kg.h)]组(PRO组),IR组和PRO组将入肝血流阻断25min后再灌注120min,然后观察不同时相丙氨酸氨基转氨酶(ALT)、天冬氨酸氨基转氨酶(AST)、乳酸脱氢酶(LDH)的变化,检测肝组织超氧化物歧化酶(SOD)活性及丙二醛(MDA)含量。结果IR组、PRO组再灌注120min后肝功能均有损害,而IR组的ALT,AST,LDH均高于PRO组;PRO组肝脏组织MDA浓度低于IR组(P<0.05),PRO组的SOD浓度高于IR组(P<0.05)。结论肝脏缺血后再灌注可使大量氧自由基释放,它在肝损伤中发挥重要作用,丙泊酚可抑制再灌注后的过度氧化反应,减轻肝组织损伤。Objective To investigate the protective effects of propofol on liver ischemia reperfusion injury in rabbits. Methods A total of 21 rabbits were averagely divided into three groups at random, i.e. sham-operation （S） group, ischemia reperfusion （IR） group and propofol （PRO） group. Rabbits suffered from ischemia for 25 min and were followed by reperfusion for 120min. The liver function, the concentration of SOD and MDA of liver tissue were determined. The histopathologic changes in the liver were also observed. Results Serum ALT, AST and LDH concentrations were markedly increased after liver ischemia reperfusion. It was found that anesthesia with propofol （ 10 mg,/kg · h^-1 ） could decrease the leakages of liver enzymes. The histopathologic hepatic changes were significantly lessened. The concentrations of SOD and MDA also showed significant differences among the three groups （ P 〈 0. 05 ）. Conclusion Propofol can protect liver from ischemia reperfusion injury to some extent.

关 键 词：二异丙酚 肝脏 再灌注损伤 氧自由基 

分 类 号：R971.2[医药卫生—药品]