阿立哌唑和氯氮平对精神分裂症患者生活质量影响的对照研究  

Comparative study on the influence of aripiprazole and clozapine on quality of life in schizophrenia

作　　者：曹红军[1] 张红梅[1] 李德重[1] 罗红霞[1] 李莹[1] 范凤兰[1] 

机构地区：[1]河南省驻马店市精神病医院,驻马店463000

出　　处：《中国行为医学科学》2007年第6期518-520,共3页Chinese Journal of Behavioral Medical Science

摘　　要：目的探讨阿立哌唑治疗对精神分裂症患者生活质量的影响。方法以阿立哌唑和氯氮平治疗精神分裂症各50例作对照研究，采用阳性和阴性症状量表（PANSS）评定临床疗效，采用副反应量表（TESS）和实验室检查评价安全性，采用世界卫生组织生活质量测定简表（WHOQOL-BREF）衡量患者生活质量。结果阿立哌唑组PANSS总分由治疗前的（92．78±18．69）分降至（41．82±9．62）分，氯氮平组PANSS总分由治疗前的（93．52±18．76）分降至（42．96±8．99）分，与治疗前比较2组均有极显著性差异（P〈0．01），2组间各时点PANSS总分比较无显著性差异（P〉0．05），但氯氮平组副作用较多。经12个月治疗，阿立哌唑组的身心健康分由治疗前的（38．76±8．57）分提高到（72．56±5．64）分，心理健康分由治疗前的（22．53±13．47）分提高到（96．67±10．83）分，社会关系分由治疗前的（18．93±14．62）分提高到（96．52±14．62）分，环境因素分由治疗前的（20．13±14．92）分提高到（95．87±10．21）分；氯氮平组身心健康分由治疗前的（39．27±8．78）分提高到（70．21±9．06）分，心理健康分由治疗前的（23．16±13．52）分提高到（80．13±10．03）分，社会关系分由治疗前的（19．31±14．56）分提高到（80．72±10．56）分，环境因素分由治疗前的（20．89±15．0）分提高到（79．89±10．51）分，2组患者生活质量均较治疗前有极显著性改善（P〈0．01），在心理健康、社会关系和环境因素方面，阿立哌唑优于氯氮平（P〈0．01）。结论在提高患者生活质量方面，阿立哌唑优于氯氮平，有利于精神分裂症的远期康复。Objective To explore the effect of aripiprazole on the quality of life in schizophrenic patients. Methods 100 patients with schizophrenia were included in this study, and 50 were treated with aripiprazole [ （ 18.96 ± 3.42） mg/d] and 50 were treated with clozapine[ （ 385.72 ± 39.69 ） mg/d]. The study persisted for 12 months. The Positive and Negative Symptom Scale （PANSS）, the Treatment Emergent Symptom Scale （TESS） and laboratory tests were used to evaluate efficacy and adverse effects of drugs, and WHOQOL-BREF instruments were used to evaluate the patients quality of life. Scales were evaluated at baseline and the end of month 1,2,3,6, 12. Descriptive analysis and paired t -test were performed in statistical analysis. Results The total PANSS scores decrease from（92.78 ± 18.69）at baseline to （41.82 ± 9.62 ）at the end of the 12th month in aripiprazole group, and the total PANSS scores decrease from（93.52 ± 18.76）to（ （42.96 ± 8.99） in clozapine group. The total PANSS scores in both groups decreased significantly after treatment （ P 〈 0.01 ）, but two groups showed similar effects, with no significance. The side effects were more in clozapine group than those in aripiprazole group. 12 months after treatment, the scores of physical health, psychological health, social relationship and environment element in aripiprazole group were 72.56 ± 5.64,96.67 ± 10.83,96.52± 14.62,95.87 ± 10.21 ; the scores of physical health, psychological health, social relationship and environment element in clozapine group were 70.21 ± 9.06, 80.13 ± 10.03,80.72 ± 10.56,79.89 ± 10.51 and the scores of four domains in WHOQOL-BREF instruments had been improved significantly in two groups（ P 〈 0.01 ）. In the domains of psychological health, social relationship and environment element, aripiprazole was superior than clozapine （ P 〈 0.01 ） . Conclusion Aripiprazole has more advantage than clozapine to improve quality of life in schizophrenia and would be helpful to patients longterm

关 键 词：阿立哌唑 氯氮平 精神分裂症 生活质量 

分 类 号：R686[医药卫生—骨科学]