大黄素胶囊小鼠急性毒性试验  

Acute Toxicity Test of Emodin Capsule in Mice

作　　者：张喜平[1] 程琪辉[2] 裘怡[3] 

机构地区：[1]杭州市第一人民医院普外科,310006 [2]杭州市第一人民医院妇产科 [3]浙江中医药大学

出　　处：《医学研究杂志》2007年第6期47-50,共4页Journal of Medical Research

基　　金：浙江省中医药卫生科技计划项目(2003C130);杭州市重大科技发展计划项目(2003123B19);杭州市医药卫生重点项目(2004Z006);杭州市131优秀中青年科技培养人才项目资助

摘　　要：目的观察大黄素胶囊灌胃1日后小鼠产生的急性毒性反应和死亡情况,以评价其安全性。方法将大黄素胶囊的内容物大黄素粉以最大浓度给ICR小鼠灌胃给药,发现小鼠没有出现死亡,未测出LD50,故测其最大给药量。结果大黄素粉最大给药量为15g/Kg。结论大黄素胶囊具有较好的安全性。Objective To observe the acute toxic reaction and death of mice one day after intragastric administration of emodin capsule so as to appraise its safety. Methods The ICR mice were intragastrically administered with emudin powder, the content of emodin capsule at maximum concentration. There was no death of mice found and no LD50 detected. Hence the maximum dosage was measured. Results The maximum dosage of emodin powder is 15g/kg. Conclusions The emodin capsule is relatively safe.

关 键 词：大黄素 急性毒性 灌胃给药 小鼠 

分 类 号：R285.5[医药卫生—中药学]