急性缺血对犬在体左心室内膜整体复极的影响  

Effect of acute ischemia on global repolarization of the left ventricular endocarium in intact canine

作　　者：刘兴利[1] 孙英贤[1] 邹德龄[1] 杨川[1] 刘双双[1] 

机构地区：[1]中国医科大学盛京医院,110004

出　　处：《山西医药杂志》2007年第6期510-512,共3页Shanxi Medical Journal

摘　　要：目的探讨急性缺血对左心室内膜整体复极的影响。方法健康犬8只,应用非接触球囊标测技术,同步记录在体阻断左前降支30min前后心内膜各区域单极电图,计算心肌激动时间(AT)、激动恢复间期(ARI)和复极时间(RT),分析相关参数的变化。结果正常供血状态下心肌内膜存在复极梯度,但由于AT与ARI呈负相关,使复极离散性很小;急性缺血后缺血区AT延迟,ARI显著缩短,AT与ARI的负向相关性消失,复极离散性明显增加(P<0·01)。结论急性缺血后,传导减慢和激动恢复时间缩短共同导致心内膜复极离散性明显增加,有利于心律失常的发生。Objective To investigate the effect of acute ischemia on global repolarization of the left ventrieular endocarium. Methods Ventricular endoeardium unipolar electrograms were recorded from 8 anesthetized canines using noncontact mapping system before and after the left anterior descending coronary artery （LAD） ligated. Activation time （AT）, activation-recovery interval （ARI） and repolarization time （RT） of all domains were calculated and analyzed. Restilts Repolarization gradients exist over the left ventricular endoeardium in normal. Because AT and ARI were negatively correlated, the dispersion of RT was small. After 30 min of acute ischemia negative correlation between AT and ARI disappeared, AT delayed and ARI deceased, repolarization dispersions increased significantly （P 〈 0.01 ） in ischemie zones. Conclusion The delayed AT and ARI are all important in increasing the dispersions of ventricular endoeardium repolarization during acute ischemia.

关 键 词：心肌缺血 心律失常 复极离散 非接触标测 

分 类 号：R541.7[医药卫生—心血管疾病]