强直性脊柱炎与肿瘤坏死因子-α基因启动子-308位点多态性关联研究的Meta分析  

The association between ankylosing spondylitis with polymorphism in -308 site of TNF-αpromoter region:the Meta analysis

作　　者：杨清锐[1] 张源潮[1] 孙红胜[1] 牟坤[2] 

机构地区：[1]山东大学山东省立医院风湿免疫科,济南250021 [2]山东大学医学院病理教研室

出　　处：《中华风湿病学杂志》2007年第6期365-369,共5页Chinese Journal of Rheumatology

摘　　要：目的探讨强直性脊柱炎(AS)与肿瘤坏死因子(TNF)-α基因启动子-308位点多态性的关联情况。方法检索已发表的有关AS和与TNF-α基因启动子-308位点多态性的文献进行Meta分析。结果8篇文献共纳入987例AS患者和922名正常对照,综合分析显示不能认为TNF-α启动了-308位点等位基因多态性与AS间存在关联,OR=0.86(0.53,1.38),P=0.53;东西方人群亚群分析结果显示不能认为东方人群TNF-α启动子-308位点等位基因多态性与AS间存在关联,OR=1.06(0.34,3.33),P=0.91;西方人群TNF-α启动子-308位点等位基因多态性可能与AS间存在关联,OR=0.75(0.59,0.96),p=0.02;在东西方人群不能认为TNF-α启动子-308位点GA+AA基因型与AS间存在相关关系.OR=0.90(0.52,1.55),P=0.69;TNF-α启动子-308位点等位基因多态性与AS无关联,独立于HLA-B27,OR=0.71(0.42,1.20),P=0.20;在中国人群,TNF-α启动子-308位点等位基因多态性与AS骶髂关节炎严重程度可能存在关联,OR=0.37(0.15,0.90),P=0.03。结论Meta分析显示西方人群TNF-α启动子-308位点等位基因多态性可能与AS间存在关联,中国人群TNF-α启动子-308位点等位基因多态性与AS间无关联,但与AS骶髂关节炎严重程度可能存在关联。Objeαive To explore the association between ankyloslng spondylitis （AS） with the polymorphism in -308 site of tumor necrosis faαor （TNF）-α promαer region. Methods The literature about AS and polymorphism in -308 site of TNF-α promαer region were searched and the meta analysis as performed. Results Eight studies enrolled 987 AS patients and 922 controls in tαal. The analysis showed that the frequencies of alleles and the genαypes had no statistical difference between AS group and the control group [OR=0.86（0.53, 1.38）, P=0.53; OR=0.90（0.52, 1.55）, P=0.69]. But the frequencies of alleles of western origin had statistical difference between AS group and the control group [OR=0.75 （0.59, 0.96）, P=0.02]; The TNF-α gene promαer polymorphism may play a role in the severity of sacroiliitis [OR=0.37（0.15, 0.90）, P=0.03） . Conclusion The meta-analysis reveales that the alleles of -308 site of TNF-α promαer region may be associated with AS in western ethnical group and play a role in the severity of sacroiliitis.

关 键 词：脊柱炎 强直性 肿瘤坏死因子α META分析 多态现象(遗传学) 

分 类 号：R593.23[医药卫生—内科学]