糖尿病大鼠心肌MDA含量、SOD和Na￣+-K￣+-ATP酶活性的变化  

^Changes of MDA content and SOD and N+ - K+ - ATPase , activities in diabetic rat myoctardium .

作　　者：蒋家华[1] 熊爱华[1] 钟玲[1] 

机构地区：[1]暨南大学医学院药理学教研室

出　　处：《中国病理生理杂志》1997年第1期70-72,共3页Chinese Journal of Pathophysiology

基　　金：广东省科委青年科学基金

摘　　要：实验用四氧嘧啶破坏Ｗｉｓｔａｒ大鼠胰腺诱发糖尿病模型，观察糖尿病人鼠心肌组织ＭＤＡ含量，ＳＯＤ和Ｎａ＋－Ｋ＋－ＡＴＰ酶活性的变化以及氧自由基清除剂（ＶｉｔＥ．亚硒酸钠）对糖尿病大鼠心肌的保护作用。结果表明：（１）糖尿病大鼠心肌组织ＭＤＡ含量显著增加（Ｐ＜０．０５），而心肌细胞膜上Ｎａ＋－Ｋ＋一ＡＴＰ酶的活性显著下降（Ｐ＜０．０１）．（２）ＶｉｔＥ和亚硒酸钠能显著降低糖尿病大鼠心肌组织ＭＤＡ含量，并能提高ＳＯＤ和Ｎａ＋－Ｋ＋－ＡＴＰ酶活性。Diahetic rats were induced by alloxan and the changes of MDA content and SOD and Na+. - K+ - ATPase activities in diabetic rat myocardium were studied. The restult.indicated that : (1 ) ln diabetic rat myocardium, MDA content was increased significantly whereas the Na+ - K+ - ATPase actiyities was decreased significantly. (2) Treat ment of the diabetic rats with Vit E and sodium selenite could inhibit the formation of MDA .and augment the activities of SOD and Na+ - K+ - ATPase significantly, These re- sults showed thal lipid peroxides produced in diabetic rat myocardium , might be one of the causes Which resulted in the decrcase of Na + - K+ - ATPase activity , on cardiac mem- brane.

关 键 词：糖尿病 丙二醛 SOD 钙 钾 ATP 

分 类 号：R587.102[医药卫生—内分泌]