几种新型抗真菌药物简介  

A Brief Introduction to Several Novel Antifungal Drugs

作　　者：刘伟[1] 李若瑜[1] 

机构地区：[1]北京大学第一医院皮肤科北京大学真菌和真菌病研究中心,北京100034

出　　处：《微生物学通报》2007年第3期617-620,共4页Microbiology China

基　　金：国家自然科学基金(No.30500027);教育部留学归国人员科研启动基金;教育部科学技术研究重点项目(No.107002)

摘　　要：脂质型二性霉素B,新型唑类药物如伏立康唑,以及作用于真菌细胞壁的药物如卡泊芬净和米卡芬净的问世,反映了抗真菌药物研究向高效、广谱、低毒的方向发展的一个特点,无疑为各种类型真菌感染的药物治疗提供了新型的有力的手段;与传统的抗真菌药物如脱氧胆酸二性霉素B和氟康唑等相比,这些药物临床疗效好,毒副作用低,对于系统性真菌感染的防治具有重大意义,文中就这方面的信息做了简介。The introduction of Lipid-formula Amphotericin B, Voriconazole, and Echinocandins, including Caspofungin and Micafungin, reflect the trend that the antifungal drugs are being developed along to a direction with high effect, broad spectrum, and low toxicity. These drugs undoubtedly provide novel useful approaches to the treatment of invasive fungal infections. Compared to the traditional antifungal drug, such as amphotericin B and Fluconasole, these drugs have the character of good effect and low adverse effect, which will be very important to prophylaxis and treatment for systemic fungal infections. The information concerning for these issues is being reviewed in this paper.

关 键 词：脂质型二性霉素B 伏立康唑 卡泊芬净 米卡芬净 

分 类 号：R978.5[医药卫生—药品]