钒酸铵对肝微粒体谷胱甘肽过氧化物酶活性影响  

Effect of ammonium metavanadate on GSH-px of liver microsomal fraction in rats

作　　者：郭宁[1] 徐明照[1] 张玉江[2] 

机构地区：[1]安徽农业大学生命科学学院,安徽合肥230036 [2]安徽大学生命科学学院,安徽合肥230039

出　　处：《安徽大学学报（自然科学版）》2007年第3期79-81,共3页Journal of Anhui University(Natural Science Edition)

摘　　要：研究钒酸铵对小白鼠肝微粒体中谷胱甘肽过氧化物酶(GSH-PX)活性的影响.采用钙沉淀法制备小白鼠肝微粒体,用GSH-PX试剂盒测定GSH-PX的活力.结果表明试验组与对照组相比,最小剂量组差异不显著(p>0.05),其余试验组差异均极显著(P<0.01),并且酶活性随着钒酸铵剂量的增大而降低.证明钒酸铵能降低小白鼠肝微粒体中GSH-PX的活性.To observe the effect of Ammonium metavanadate on GSH - PX of liver microsomal fraction in rats. The method of Calcium sediment was prepared for microsomal fraction of rats. The GSH - PX vitality was determined with GSH -PX reagent box. Results： Compared with control group, there was no significant difference of the min dosage group （p 〉 0.05 ）. But there were extremely significant difference of other experiment groups （p 〈 0. 01 ） with control group. And the GSH - PX vitality was reduced along with promoting dosage. Conclusion： GSH -PX vitality were reduce by Ammonium metavanadate.

关 键 词：钒酸铵 肝微粒体 谷胱甘肽过氧化物酶 

分 类 号：Q55[生物学—生物化学]