重症肌无力132例手术治疗分析  

Clinical analysis of 132 cases of myasthenia gravis patients with thymectomy

作　　者：罗凌青[1] 张建中[1] 翁杰[1] 

机构地区：[1]海南医学院附属医院胸外科,海南省海口570102

出　　处：《中国基层医药》2007年第5期711-713,共3页Chinese Journal of Primary Medicine and Pharmacy

摘　　要：目的 探讨重症肌无力的临床病理特点及合理的外科治疗方案。方法 回顾性分析132例重症肌无力患者外科治疗的临床资料．按改良Osserman标准分型：Ⅰ型33例，Ⅱa型39例，Ⅱb型40例，Ⅲ型16例，Ⅳ型4例；伴发胸腺瘤23例，胸腺增生91例，胸腺正常12例，胸腺萎缩6例。以累积生存率、转归为指标进行统计分析。结果 术后经过1～16年的随访观察，缓解35例（26．5％），有效94例（71．2％），无改善37例（28．0％），无死亡。结论 胸腺切除治疗MG是一种安全、有效的方法，病程、伴胸腺增生、临床分型与手术治疗效果相关。Objective To review the experience of diagnosis and surgical treatment of myasthenia gravis. Methods 132 patients with myasthenia gravis were operated on from January 1989 to January 2005 in our department. According osseman clinical classification ：stage Ⅰ in 33 cases,stage Ⅱ a in 39 cases,stage Ⅱb in 40 cases, stage Ⅲ in 16 cases,stage Ⅳ in 4 cases. Among the 132 cases of myasthenia gravis,91 accompanied with thymus hyper plasia,23 with thymus gland lump, 12 with thymus normal,and 6 with thymus atrophy. Statistic analysis performed in terms of accumulated survival rate and MG turnover. Results All cases were followed up from 12 to 192 months. The remission rate was 26.5 % （35/132 ）, the improvement rate was 38.8 % （ 94/132 ）, 37 （28.0 % ） patients showed no change. Conclusion An effective method to treat MG, thymectomy should be performed on most of the MG patients early and actively.

关 键 词：重症肌无力 胸腺切除术 手术治疗 

分 类 号：R6[医药卫生—外科学] R74[医药卫生—临床医学]