辛伐他汀对高脂血症患者的调脂及降低炎性细胞因子水平临床观察  

The Effects of Simvastatin on Lipid Profile Modification and Proinflammatory Cytokines in Hyperlipidemic Patients

作　　者：管仁莲[1] 汉吉洪[1] 王喆[1] 刘芬[1] 吕祖英[1] 

机构地区：[1]日照市人民医院内分泌科,山东日照276800

出　　处：《潍坊医学院学报》2007年第2期166-167,共2页Acta Academiae Medicinae Weifang

摘　　要：目的观察辛伐他汀对高脂血症患者的调脂及降低炎性细胞因子如：IL-6、TNF-α水平的作用,并探讨他汀类药物调脂外作用机制。方法选取高脂血症患者40例,空腹抽静脉血测定其血清总胆固醇（TC）、甘油三酯（TG）、低密度脂蛋白胆固醇（LDL-C）及血清IL-6、TNF-α水平;给予辛伐他汀20～40mg/d,治疗2周后复查上述指标,并与治疗前及对照组进行比较。结果用药后较用药前患者血清TC、LDL-C、TG均下降,差异有显著性（P〈0.05）,血清IL-6、TNF-α水平显著下降,差异亦有显著性（P〈0.05）。结论高脂血症患者给予辛伐他汀治疗不仅有调脂作用,亦可明显降低炎性细胞因子水平,这可能有利于动脉粥样硬化斑块的稳定。Objective To investigated the effects of simvastatin on lipid profile modification and proinflammatory cytokines levels in hyperlipidemic patients. Methods Hyperlipidemic patients （ n = 40） were treated with 20 - 40mg simvastatin. Blood samples were taken before and 2 weeks after the administration of the statin to evaluate serum concentrations of interleukin-6（IL-6） and tumor necrosis factor-alpha （TNF-alpha）. Results After treatment with simvastatin, the serum levels of TG, TC, LDL- C were significantly decreased （ P 〈 0.05 ）, and the serum levels of IL-6 and TNF-alpha also significantly decreased（ P 〈 0.05 ）. Conclusion Simvastatin can decrease the levels of proinflammatory cytokines, besides the effects of lipid profile modification.

关 键 词：辛伐他汀 调脂作用 细胞因子 

分 类 号：R589.2[医药卫生—内分泌]