门诊2型糖尿病病人治疗现状分析  

Therapeutic Survey on Outpatient with Type 2 Diabetes

作　　者：郭英[1] 李琰琳[1] 张爱华[1] 刘伊辉[2] 侯纯荣[1] 

机构地区：[1]潍坊医学院附属医院内分泌科,山东潍坊261031 [2]中国石油化工股份有限公司催化剂齐鲁分公司职工医院

出　　处：《潍坊医学院学报》2007年第2期168-169,共2页Acta Academiae Medicinae Weifang

摘　　要：目的了解门诊2型糖尿病病人治疗达标情况,提出有效的治疗措施。方法将门诊2型糖尿病病人380例按以往治疗情况分为二甲双胍组、优降糖组、二甲双胍+迪沙片组、二甲双胍+诺和龙组、二甲双胍+格列美脲组、二甲双胍+胰岛素组,观察3个月。观察前后分别行常规体格检查,检测血糖、血脂、糖化血红蛋白、肝、肾功能及空腹胰岛素水平。结果各组病人的血糖、糖化血红蛋白均较治疗前下降,胰岛素敏感性增加,二甲双胍+胰岛素组疗效优于其他治疗组(P<0.01)。结论2型糖尿病病人治疗达标率较低,联合口服降糖药物治疗优于单一口服降糖药。对口服降糖药效果差的病人,应尽早联合用药或选择胰岛素治疗。Objective To investigate the therapeutic effect of outpatient with type 2 diabetes and to provide effective measures. Methods According to the therapeutic scheme, 380 patients with type 2 diabetes were divided into six groups, which were treated respectively with mefformin, glibenclamide, metformin ＋ glipizide, metformin ＋ NovoNorm, mefformin ＋ glimepiride, or metformin ＋ insulin. Each patient accepted routin physical examination, and the fasting blood sugar （FBS）, blood lipid, fasting insulin （FINS）, glycosylate hemoglobin （HbA1c）, hepatic and renal function were assessed at the beginning and after three months treatment. Results FPG, HbA1c of each group decreased and insulin sensitivity significantly improved after the treatment. The effect of mefformin ＋ insulin group was better than others （ P 〈 0. 01 ）. Conclusions The therapy on outpatient with type 2 diabetes was less effective treated. Combined oral hypeglycemic agents are better than single oral hypeglycemic agent. To achieve better effects, the diabetics who were terribly treated with single oral hypeglycemic agents should be treated with combined ones or insulin as soon as possible.

关 键 词：2型糖尿病 药物治疗 胰岛素 

分 类 号：R587.1[医药卫生—内分泌]