3-芳氧基-6-(3,5-二甲基-1H-吡唑-1-基)哒嗪的合成及生物活性  

Synthesis and Biological Activity of 3-Aryloxy-6-(3,5-dimethyl-1H-pyrazol-1-yl)-pyridazine

作　　者：胡方中[1] 张桂峰[1] 朱有全[1] 邹小毛[1] 刘斌[1] 杨华铮[1] 

机构地区：[1]南开大学元素有机化学研究所元素有机化学国家重点实验室,天津300071

出　　处：《有机化学》2007年第6期758-762,共5页Chinese Journal of Organic Chemistry

基　　金：国家自然科学青年基金(No.20302004)资助项目.

摘　　要：为了寻找高活性的先导化合物,以3,6-二氯哒嗪为原料,经过三步反应,合成了一系列未经文献报道的3-芳氧基-6-(3,5-二甲基-1H-吡唑-1-基)哒嗪.所有新化合物的结构均经过1H NMR,IR,LC-MS和元素分析确认.初步的生物活性测试表明,所合成的化合物都有一定的除草活性.In order to find highly active lead compounds, a series of new pyridazine derivatives have been synthesized using 3,6-dichloropyridazine as starting material by a three-step synthetic route. The structures of all compounds were confirmed by ^1H NMR, IR, LC-MS spectra and elemental analysis. The preliminary bioassay results showed that all of the compounds possessed some extent herbicidal activity.

关 键 词：哒嗪 吡唑 合成 生物活性 

分 类 号：TQ450.1[化学工程—农药化工]