5-芳甲氧基-3(2H)-哒嗪酮衍生物的设计、合成与生物活性  

Design, Synthesis and Biological Activity of 5-Oxo-3(2H)-pyridazinone Derivatives

作　　者：凌云[1] 李洪森[1] 杨新玲[1] 鲍涵[1] 邱立红[1] 陈馥衡[1] 

机构地区：[1]中国农业大学应用化学系,北京100094

出　　处：《有机化学》2007年第6期763-767,共5页Chinese Journal of Organic Chemistry

基　　金：国家自然科学基金(No.20272080);国家重点基础研究发展计划(973计划)(No.2003CB114400)资助项目

摘　　要：为寻找新型昆虫生长调节活性化合物,设计合成了15个未见文献报道的5-芳甲氧基取代的3(2H)-哒嗪酮衍生物,所有化合物结构均通过1H NMR,IR和元素分析确证.初步生物活性研究表明,化合物8o对2龄家蝇幼虫有明显的抑制作用;化合物8a,8c,8g和8j对3龄蝗蝻显示出较好的生物活性.对目标化合物的构效关系亦进行了初步探讨.In order to search for new insect growth regulators, fifteen new compounds containing 5-oxo- 3（2H）-pyridazinone derivatives were designed and synthesized. Their structures were confirmed by ^1H NMR, IR spectra and elemental analysis. In the preliminary bioassay test, compound 8o obviously disrupted the development of second-instar housefly larvae. Compounds 8a, 8c, 8g and 8j also showed good activity against the third-instar nymphs of locusts （Locusta migratoria manilensis）. The structure-activity relation- ship of compounds was also discussed.

关 键 词：哒嗪酮 合成 生物活性 构效关系 

分 类 号：TQ452[化学工程—农药化工]