经静脉心肌造影对犬冠状动脉阻断后存活心肌评价的实验研究  

Assessment of viable myocardium after coronary artery occlusion using myocardial contrast echocardiography

作　　者：杨军[1] 佟玉章[2] 郭启勇[3] 任卫东[4] 

机构地区：[1]中国医科大学附属盛京医院超声科,辽宁沈阳110003 [2]中国医科大学附属第一医院局解教研室 [3]中国医科大学附属盛京医院放射科,辽宁沈阳110003 [4]中国医科大学附属第一医院心功能科

出　　处：《中国医科大学学报》2007年第3期278-279,共2页Journal of China Medical University

基　　金：辽宁省教育厅基金资助项目(2005L489)

摘　　要：目的:探讨经静脉心肌造影(MCE)对犬冠状动脉阻断后存活心肌判定的价值。方法:应用自制声学造影剂,对12条犬于冠状动脉阻断即刻、阻断后1h、4h和再灌注后1h进行经静脉心肌造影研究。结果:当冠状动脉阻断后,所有犬阻断的冠状动脉供血区心肌出现节段性的灌注缺损。阻断即刻与1h的灌注缺损区面积无明显差异,而阻断4h后灌注缺损面积较前两者变小,在阻断早期灌注缺损区域部分变为正常或灌注减低区。灌注减低区对应的氯化三苯四氮唑染色显示为存活心肌。结论:冠状动脉阻断一定时间后MCE可以准确判定存活心肌。Objective： To discuss the value of the assessment of viable myocardium after coronary artery occlusion by using myocardial contrast echocardiography （MCE）. Methods： Twelve opened-chest mongrel dogs underwent MCE with intravenous injection of selfmade contrast agent immediately, l hour, and 4 hours after coronary artery occlusion and 1 hour after reperfusion. Results： The segmental perfusion defects were found in all dogs after coronary artery occlusion. There was no significant difference in the perfusion defect size in dogs immediately and 1 hour after coronary artery occlusion, but the perfusion defect size 4 hours after coronary artery occlusion was smaller than that immediately or 1 hour after coronary artery occlusion. The perfusion defect area became normal or diminished perfusion area. The myocardium in the diminished perfusion area was viable, which was confirmed by triphenyltetrazolium chloride （TTC） staining. Conclusion： The viable myocardium can be assessed correctly with MCE after coronary artery occlusion.

关 键 词：心肌造影 存活心肌 冠状动脉 

分 类 号：R543.3[医药卫生—心血管疾病] R445[医药卫生—内科学]