缬沙坦对糖尿病肾病大鼠肾脏氧化应激的影响  

Effects of valsartan on oxidative stress in kidney of diabetic rats

作　　者：钟艺[1] 黄淑妍[2] 陈澍[3] 刘雪芳 张一萍[1] 

机构地区：[1]广州医学院第二附属医院药学部,510260 [2]广州医学院第二附属医院老年病科,510260 [3]广州医学院第二附属医院内分泌科,510260 [4]广东省增城市人民医院内科

出　　处：《中国药物与临床》2007年第6期417-419,共3页Chinese Remedies & Clinics

基　　金：广州市中医药中西医结合科研立项基金资助项目(2006B39)

摘　　要：目的观察缬沙坦干预治疗后糖尿病大鼠肾脏氧化应激的变化,探讨缬沙坦保护肾脏的部分机制。方法以链脲佐菌素建立糖尿病大鼠模型,缬沙坦干预治疗10周,观察大鼠糖代谢、肾功能及肾皮质内丙二醛(MDA)含量、超氧化物歧化酶(SOD)活性。结果糖尿病大鼠糖化血红蛋白、血尿素氮、24h尿总蛋白、尿白蛋白定量(24h)、24h尿量、肾皮质MDA含量显著升高;肾皮质SOD活性显著降低。缬沙坦干预治疗组上述指标改善,差异有统计学意义。结论氧化应激参与了糖尿病肾病(DN)的发病过程,缬沙坦对DN的治疗作用部分是通过抗氧化实现的。Objective To observe the protective effects of valsartan （an angiotensin receptor blocker） on oxidative stress in diabetic rats and to study the possible mechanisms underlying valsartan＇s protection against diabetic nephropathy. Methods Diabetic rat models induced by single-dose intraperitoneal injection of streptozocin （STZ） were treated with valsartan for 10 weeks and assessed for changes in glucose metabolism, kidney function, and levels of MDA and superoxide dismutase （SOD） in the renal cortex. Results Significantly, the levels of blood HbA,c, blood urea nitrogen, 24 hour total urine proteins and albumins, and cortical MDA content were increased and SOD level decreased in the DN models. All these parameters were remarkably improved with valsartan intervention. Conclusion Valsartan decreased the urine albumin excretory rate in rats with diabetes mellitus nephrothy, which may be at least partly correlated with the reduction of oxidative stress in kidney.

关 键 词：糖尿病.肾病 氧化性应激 血管紧张素Ⅱ1型受体拮抗剂 缬沙坦 

分 类 号：R96[医药卫生—药理学]