冠心病患者血清载脂蛋白AI、B_(100)与组织型纤溶酶原激活剂及其抑制物的相关性  

Relationship Between Serum Apolipoprotein A I,B 100 and Plasma Tissue Plasminogen Activator,Plasminogen Activator Inhibitor in Patients With Coronary Heart Disease

作　　者：王聪霞[1] 孙济川[1] 田清海[1] 丁抗宁[1] 张进虎 岳天海[1] 

机构地区：[1]西安医科大学第二附属医院心内科

出　　处：《中国循环杂志》1997年第1期20-23,共4页Chinese Circulation Journal

摘　　要：目的：探讨载脂蛋白ＡＩ、Ｂ１００与冠心病患者组织型纤溶酶原激活剂（ｔ－ＰＡ）及其抑制物活性的关系。方法：对５２例冠心病患者和２５例健康人用免疫比浊法测定血清载脂蛋白ＡＩ、Ｂ１００浓度，并以发色底物法测定血浆组织型纤溶酶原激活剂及其抑制物的活性。结果：冠心病各类型中，急性心肌梗死（ｎ＝１２）及不稳定性心绞痛（ｎ＝１９）组载脂蛋白Ｂ１００、纤溶酶原激活剂抑制物活性显著高于对照组（Ｐ＜０．０１和Ｐ＜０．００１）；载脂蛋白ＡＩ、组织型纤溶酶原激活剂显著低于对照组（Ｐ＜０．００１和Ｐ＜０．０１）。在稳定性心绞痛组（ｎ＝２１），载脂蛋白Ｂ１００和纤溶酶原激活剂抑制物亦升高（Ｐ＜０．０５），载脂蛋白ＡＩ与组织型纤溶酶原激活剂亦降低（Ｐ＜０．０５）。相匹配的不稳定性心绞痛及对照组各１９例的相关分析发现载脂蛋白Ｂ１００与组织型纤溶酶原激活剂活性无关，而载脂蛋白Ｂ１００与纤溶酶原激活剂抑制物活性均呈正相关（ｒ＝０．８３３０和ｒ＝０．７７２９），载脂蛋白ＡＩ与纤溶酶原激活剂抑制物活性均呈负相关（ｒ＝－０．６７３４和ｒ＝－０．８６７４）。结论：载脂蛋白ＡＩ、Ｂ１００浓度与纤溶酶原激活剂抑制物活性之间存在相关关系；载脂蛋白ＡＩ与纤溶?Objective:To study the relationship between serum apolipoprotein A I and B 100 (Apo A I,B 100 ) and plasma tissue type plasminogen activator (t PA) and plasminogen activator inhibitor 1 (PAI 1) in patients with coronary heart disease. Methods:Serum Apo A I and Apo B 100 of 52 cases with coronary heart disease and 25 controls were measured by immunoturbidimetry.Meanwhile,plasma t PA and PAI 1 were determined by spectrophotometry. Results:The concentration of Apo B 100 and PAI 1 activity in acute myocardial infarction ( n =12) and unstable angina pectoris ( n =19) were significantly higher than those of the control group( p <0 01 and 0 001,respectively).The concentration of Apo A I and t PA activity were obviously lower than those of the controls( p <0 001 and 0 01,respectively).In stable angina pectoris( n =21),Apo B 100 and PAI 1 also increased ( p <0 05);but Apo A I and t PA decreased( p <0 05).The concentration of Apo B 100 did not correlate with plasma t PA activity in 19 cases of matched unstable angina pectoris and control;but positively correlated with PAI 1 activity ( r =0 8330; r =0 7729),and the concentration of Apo A I negatively correlated with PAI 1 activity in both groups( r =-0 6734; r =-0 8674). Conclusion:The concentration of Apo A I and Apo B 100 may reflect PAI 1 activity,the former shows negative correlation while the latter shows positive correlation with PAI 1 activity.

关 键 词：冠心病 载脂蛋白 T-PA 抑制物 

分 类 号：R541.402[医药卫生—心血管疾病]