糠尿病大鼠血及肝肾中铬锌铜含量的变化  

Changes in Contents of Chromium, Zinc and Copper in the Blood,Liver and Kidney of Diabetic Rats

作　　者：吴建峰 陈清[1,2] 高兆华 王耐芬[1,2] 王小燕 

机构地区：[1]南通卫生检疫局江苏省 [2]北京医科大学公共卫生学院

出　　处：《中华预防医学杂志》1997年第1期37-39,共3页Chinese Journal of Preventive Medicine

摘　　要：为了研究糖尿病患者体内微量元素的变化，采用原子吸收石墨炉法及火焰法分别对链脲佐菌素诱导的糖尿病大鼠血（血清）、肝及肾中的铬、锌、铜的含量进行了３周的观察。结果表明：在整个观察期间，与正常大鼠相比，糖尿病大鼠肝铬含量明显升高，肾铬含量明显下降；肝、肾中的锌、铜及血清铜含量均呈不同程度的升高。在所观察的３周内，未发现糖尿病大鼠血（血清）、肝、肾中铬、锌、铜含量随病程而变化；而大鼠体内微量元素的变化与其血糖值关系密切，肝中铬、锌、铜含量及肾中锌、铜含量与血糖呈正相关关系，肾铬含量与之呈负相关关系。因而，改善糖尿病大鼠的血糖情况可能会在一定程度上控制其体内微量元素的紊乱。Contents of chromium,zinc and copper in the blood (or serum) ,liver and kidney of diabetic rats induced by streptozotocin were determined for three weeks by graphite stove and flame atom absorption spectrophotometry to study the changes in trace elements in diabetics.Results showed liver chromium level increased significantly and kidney chromium level lowered significantly in diabetic rats,as compared with normal ones. Zinc and copper in liver and kidney and serum copper also increased to various extent during three week observation period.No changes in chromium,zinc and copper levels in blood (or serum), liver and kidney,with the course of the disease,were observed.But,contents of trace elements in rats correlated with their blood sugar levels closely,and chromium,zinc and copper contents in the liver correlated with those in the kidney directly,and with chromium content in the kidney inversely.Therefore,improvement of blood sugar level in diabetic rats may,to a certain extent,improve the disturbance of trace elements in the body.

关 键 词：铬 锌 铜 糖尿病 血液 肝 肾 

分 类 号：R587.102[医药卫生—内分泌]