三七总皂苷微孔渗透泵控释片体外释放度研究  

Release in-vitro of panax notoginoside micro-porous osmotic pump tablets

作　　者：钟玲[1] 臧志和[1] 

机构地区：[1]成都医学院,四川成都610083

出　　处：《中成药》2007年第6期821-824,共4页Chinese Traditional Patent Medicine

摘　　要：目的:研究三七总皂苷微孔渗透泵控释片的体外释放度。方法:考察不同溶出方法、搅拌桨速度和溶出介质对三七总皂苷微孔渗透泵控释片体外释药的影响。结果:溶出方法、桨叶转速以及溶出介质的pH值在3.5～7.6范围内时,对三七总皂苷渗透泵片体外释药行为无显著影响,但溶出介质的pH值在1.0时会严重影响渗透泵片药物的释放。结论:除酸性介质条件外,三七总皂苷微孔渗透泵片体外释药特征稳定。AIM ： To study release rate in-vitro of the panax notoginoside micro-porous osmotic pump （MPOP） tablets. METHODS： To investigate the effects of different dissolution methods, paddle stirring rate and dissolved mediums on the release rate in-vitro of the panax notoginoside MPOP tablets. RESULTS： The delivery rate was not influenced by the dissolution methods, paddle stirring rate and when the pH of dissolution medium was between 3.5-7.6, the delivery rate was not influenced, too. However, when the pH of dissolved medium was at 1.0, the release rate was decreased severely. CONCLUSION： Panax notoginoside MPOP tablets have a stable release curve except for in the condition of the acid dissolved medium.

关 键 词：三七总皂苷 微孔渗透泵片 体外释放度 酸性介质 

分 类 号：R927.1[医药卫生—药学]