卡维地洛固体分散体的初步研制  

Preparation of Carvedilol Solid Dispersion

作　　者：侯永利[1] 杨建彬[2] 

机构地区：[1]邢台医学高等专科学校,邢台市054000 [2]邢台市人民医院,邢台市054001

出　　处：《中国药房》2007年第16期1239-1241,共3页China Pharmacy

基　　金：河北省科技发展计划项目(02276414)

摘　　要：目的:制备卡维地洛固体分散体并考察其体外溶出度。方法:以聚乙二醇(PEG)、聚乙烯吡咯烷酮(PVP)的混合物(2∶1、1∶2)为载体,采用溶剂熔融法和共沉淀法制备载体与药物不同比例的固体分散体并比较其体外溶出度。结果:药物溶出度随载体比例增加而增加;载体与药物比例越小,固体分散体与药物原料粉之间溶出度差异越显著;PEG∶PVP(1∶2)所制分散体体外溶出行为较优,以3、10、30、60min时溶出百分率进行比较,固体分散体是药物原料粉的3～8倍。结论:所制卡维地洛固体分散体能增加药物体外溶出度。OBJECTIVE： To prepare carvedilol solid dispersion and to study its dissolution. METHODS： Different proportions （carrier/drug） of carvedilol solid dispersion were prepared by solvent-melting method and coprecipititation method with PEG and PVP as carriers （2 ： 1, 1 ： 2） . The in vitro dissolution characteristics pf the dispersion were compared. RE- SULTS.. The drug dissolution increased with the increase of the proportion of carriers; the lower the ratio of carrier/drug was, the greater the differences between the dissolution of solid dispersion and that of raw drug power. The in vitro dissolution of solid dispersions with PEG ： PVP（1 ： 2）as the carrier was optimal, which were 3-8 times those of raw drug powder at 3, 10, 30 and 60 min. CONCLUSION. The prepared solid dispersion showed increased drug dissolution in vitro.

关 键 词：卡维地洛 固体分散体 溶出度 聚乙二醇 聚乙烯吡咯烷酮 制备 

分 类 号：R943[医药卫生—药剂学] R972[医药卫生—药学]