藏药紫金标抗HSV-1作用的体内实验研究  

The anti-HSV-1 activity of Ceratostigma willmattianum in vivo

作　　者：陈恬[1] 贾文祥[2] 曾蔚[2] 张再容[2] 杜宝中[2] 李晖 陈金瑞 

机构地区：[1]成都医学院病原生物学教研室,成都610081 [2]四川大学华西基础医学与法医学院,成都610041 [3]西藏高原生物研究所,拉萨850002

出　　处：《中国人兽共患病学报》2007年第6期562-565,共4页Chinese Journal of Zoonoses

基　　金：西藏自治区科委重点项目(20031204);四川省教育厅青年项目(2005C019);四川省青年科技基金(06ZQ026024)

摘　　要：目的探讨藏药紫金标抗单纯疱疹病毒I型(HSV-1)的体内作用。方法对小鼠进行HSV-1的角膜局部接种、尾静脉全身接种两种HSV-1感染的动物模型,观察紫金标对疱疹性角膜炎和HSV-1全身感染的治疗作用。结果紫金标可减轻组织的病理损害,明显减少或消除脏器内的病毒抗原,最大无毒剂量(0.3g/kg/d)的紫金标对HSV-1有明显的对抗作用,其效果与临床用的抗病毒药物ACV近似;紫金标对疱疹性角膜炎有治疗作用。结论紫金标有抗HSV-1的药效学作用,对疱疹性角膜炎和HSV-1全身感染有较明显的治疗作用。To examine the antiviral effect of extract from Ceratostigma willmattianum against herpes simplex virus type- 1 （HSV-1） and to assess its potential for clinical applications. Two animal models of HSV-1 infection were used by local-inoculation on the cornea and full-inoculation through tail vein of mice, and then treated with the extract from C. willrnattianurn with different doses. Meanwhile, ACV was employed as a positive control. The focus of the experiments was on the remedial action of C. willrnattianurn to HSV-1 full-infection abouta variety of viscera pathology and the time of appearance and disap- pearance of antigen. It was also aimed at the remedial action to herpes simplex keratitis （HSK） from the acreage variety of cornea pathological changes. Results showed that Ceratostigrna willrnattianurn could decrease the pathological changes in viscera, and eliminate the virus antigen notably, with the effects at a dosage of 0. 3 g/kg/d, equal to those of positive coutrol drug ACV. The data thus seem to indicate Ceratostigrna willrnattianurn has remedial action to HSK.

关 键 词：紫金标 单纯疱疹病毒Ⅰ型 抗病毒作用 体内实验 

分 类 号：R373.9[医药卫生—病原生物学]