伤疡愈软膏对烫伤大鼠创面碱性成纤维细胞生长因子表达水平的影响  

Effects of Shangyangyu Ointment on the Expression of b-FGF of the Scalded Wound of Rats

作　　者：常宏[1] 伍倩[1] 谢东 

机构地区：[1]深圳市妇幼保健院,深圳市518028 [2]深圳市人民医院,深圳市518003

出　　处：《中国药房》2007年第18期1375-1376,共2页China Pharmacy

摘　　要：目的:探讨伤疡愈软膏对烫伤大鼠创面愈合过程中碱性成纤维细胞生长因子(b-FGF)表达水平的影响。方法:选择SD大鼠60只,随机分为A、B、C组,每组20只。A组为正常对照组,B、C组复制烫伤动物模型,其中B组大鼠经常规处理,C组大鼠使用伤疡愈软膏治疗。愈合过程中取组织溶浆液,应用逆转录聚合酶反应检测烫伤创面b-FGF mRNA的表达水平。结果:与A组比较,B、C组大鼠创面b-FGF mRNA的表达水平有显著差异;与B组比较,C组大鼠烫伤创面愈合时间显著缩短。结论:伤疡愈软膏可促进创面愈合,提高b-FGF mRNA的表达水平。OBJECTIVE：To discuss the effects of Shangyangyu ointment on the expression of b-FGF of the scalded wound in rats during the healing process of wound surface. METHODS： 60 SD rats were randomly and equally divided into 3 groups （ n = 20） ： group A was established as normal control group, group B and group C were selected to establish the scalding model, of which, group B was given routine treatment while group C was treated with Shangyangyu ointment. During healing process, the serous fluid of tissue was taken from the scalded wound, with the expression of b-FGF mRNA determined by reversed transcription-polymerase-chain-reaction （RTPCR）. RESULTS：The expression levels of b-FGF mRNA of the scalded wound in group B and group C were of significant difference as compared with group A. And the healing time was significantly shorter in group C as compared with group B. CONCLUSION：Shangyangyu ointment can promote the healing process of the wound and elevate the expression level of b-FGF mRNA.

关 键 词：伤疡愈软膏 烫伤 碱性成纤维细胞生长因子 动物模型 

分 类 号：R285.5[医药卫生—中药学] R283.621[医药卫生—中医学]