生长激素雌激素对去势大鼠剩余牙槽骨内IGF-I表达的影响  

The effects of estrogen and recombine human growth hormone on the express of IGF-I in maxillary in osteoporotic rats

作　　者：唐成芳[1] 郭三萍[2] 李晓红[2] 朱勇[1] 娄鸣[1] 肖卓[2] 胡亚军[2] 

机构地区：[1]西安医学院口腔医学系,西安710004 [2]西安交通大学口腔医院修复科

出　　处：《中国骨质疏松杂志》2007年第6期393-397,共5页Chinese Journal of Osteoporosis

基　　金：陕西省科学技术研究发展计划项目[2003K10-G78(1)]

摘　　要：目的观察生长激素、雌激素及两者联合运用对切除卵巢大鼠剩余牙槽骨内胰岛素样生长因子分布和表达的影响。方法通过去除SD大鼠双侧卵巢,拔除单侧上颌磨牙,建立骨质疏松的剩余牙槽骨动物模型,并在此基础上通过免疫组化方法观察、分析切除卵巢及单独和联合运用生长激素、雌激素对去势大鼠剩余牙槽骨内胰岛素样生长因子分布和表达的影响。结果骨质疏松组局部牙槽骨内的IGF-I表达最弱,雌激素、生长激素以及两者联合运用都能通过增加IGF-I在骨组织局部的表达量提高成骨的活性,检验有统计学意义(P<0.05)。生长激素及联合用药的效果优于单独运用雌激素,联合用药组提高IGF-I表达的效果略高于单用生长激素组,但无统计学意义(P>0.05)。结论雌激素、生长激素及两药联合运用能通过增加IGF-I表达延缓牙槽骨吸收。Objective The aim of this study was to study the effect of estrogen and recombine human growth hormone on the express of IGF-I in Maxillary in osteoporotic rats. Methods Animal models were established by ovariectomy and exodontia on left partial Maxillary. And the effects of estrogen and recombine human growth hormone on the distribution of IGF-I in Maxillary were observed in OP rats. The feasibility of using estrogen and recombine human growth hormone to reduce Resorption of Residual Ridge in OP rats was investigated in order to offer the theoretic guidance for OP patients to reduce Resorption of Residual Ridge and jaws and improve the effects of false tooth. Results The immunohistochemistry of IGF-lstraining slices showed that the expression of IGF-I in the Residual Ridge of Osteoporosis group was the weakest. All three treatment group can increase the expression of IGF-I in bone and improve the effect of osteoblast. The effect was better in Er-HGHT group and r-HGHT group than in ERT group and the effect was slightly better in Er-HGHT group than in r-HGHT group, but statistic test had no obvious direction. Conclusion Estrogen and recombine human growth hormone and their combination can relive the resorption of residual ridge by increasing the expression of IGF-I.

关 键 词：骨质疏松 剩余牙槽骨 重组人生长激素 雌激素 IGF-I 

分 类 号：R714.51[医药卫生—妇产科学]