Clinical Experience in Treatment of Amanita Mushroom Poisoning with Glossy Ganoderma Decoction (灵芝煎剂) and Routine Western Medicines  

作　　者：肖桂林 张春虎 刘发益 陈作红 胡随瑜 

机构地区：[1]Xiangya Hospital Affiliated to Central South University [2]Xiangya School of Medicine, Central South University [3]Institute of Poisonous Mushrooms, Life Science School of Hunan Normal University

出　　处：《Chinese Journal of Integrative Medicine》2007年第2期145-147,共3页中国结合医学杂志（英文版）

基　　金：Supported by the Funds from Hunan Provincial Administration of Traditional Chinese Medicine (No 204054)

摘　　要：Objective： To assess the effects of treatment of Amanita mushroom poisoning with Glossy anoderma Decoction （灵芝煎剂, GGD）. Methods： Twelve patients with acute Amanita mushroom poisoning received conventional treatment （penicillin and reduced glutathione） combined with oral administration of GGD （treated group）, which was prepared out of 200 g Glossy ganoderma decocted in water to 600 mL, and 200 ml was given once, three times a day for 7 successive days; while conventional treatment alone was given to the other 11 patients assigned to the control group. The therapeutic efficacy and changes in serum levels of total bilirubin （TBil）, bile acids （BA）, alanine transaminase （ALl-）, and aspartate transaminase （AST） activities in the two groups were compared. Results： The cured- markedly effective rate in the treated group was more significant than that in the control group （P〈0.01）. Elevation in TBil, BA, ALT, and AST activities were observed in both groups 3 days after poisoning, which progressively increased thereafter in the control group. In the treated group, they reached their peak on the 3rd day and then declined gradually. The differences between pre-treatment and post-treatment in both groups were obviously significant （P〈0.01）, so were the differences between the two groups at corresponding time points （P〈0.01）. Conclusion： GGD shows excellent clinical efficacy in the treatment of acute Amanita mushroom poisoning and can reduce mortality significantly.Objective： To assess the effects of treatment of Amanita mushroom poisoning with Glossy anoderma Decoction （灵芝煎剂, GGD）. Methods： Twelve patients with acute Amanita mushroom poisoning received conventional treatment （penicillin and reduced glutathione） combined with oral administration of GGD （treated group）, which was prepared out of 200 g Glossy ganoderma decocted in water to 600 mL, and 200 ml was given once, three times a day for 7 successive days; while conventional treatment alone was given to the other 11 patients assigned to the control group. The therapeutic efficacy and changes in serum levels of total bilirubin （TBil）, bile acids （BA）, alanine transaminase （ALl-）, and aspartate transaminase （AST） activities in the two groups were compared. Results： The cured- markedly effective rate in the treated group was more significant than that in the control group （P〈0.01）. Elevation in TBil, BA, ALT, and AST activities were observed in both groups 3 days after poisoning, which progressively increased thereafter in the control group. In the treated group, they reached their peak on the 3rd day and then declined gradually. The differences between pre-treatment and post-treatment in both groups were obviously significant （P〈0.01）, so were the differences between the two groups at corresponding time points （P〈0.01）. Conclusion： GGD shows excellent clinical efficacy in the treatment of acute Amanita mushroom poisoning and can reduce mortality significantly.

关 键 词：Amanita mushroom POISONING Glossy ganoderma Decoction 

分 类 号：R285[医药卫生—中药学]