肠道小RNA病毒组所致脑膜炎的病原体特点及其诊断  

Characteristics of Pathogens and the Diagnosis on the Meningitis from Picornavirus Group

作　　者：杨亚平[1] 关慧臻[1] 薛承岩[1] 张凤侠[1] 李桂洁[1] 

机构地区：[1]承德医学院附属医院,河北承德067000

出　　处：《现代检验医学杂志》2007年第3期5-6,共2页Journal of Modern Laboratory Medicine

基　　金：2006年承德市科学技术研究与发展计划项目(项目编号:200622020)

摘　　要：目的探索肠道小RNA病毒组所致病毒性脑膜炎的病原体特点及诊断方法。方法病毒性脑膜炎患者(病脑组)和非病毒性脑膜炎患者(对照组)为观测对象,应用反转录聚合酶链反应技术(RT-PCR)检测脑脊液标本肠道小RNA病毒组及柯萨奇病毒(COX)。结果病脑组肠道小RNA病毒组总检出率为34.5%,其中COX为29.1%;对照组未检出此类病毒。结论RT-PCR是检测肠道小RNA病毒较实用的方法,肠道小RNA病毒组尤其是其中的COX是导致病脑的重要病原体,应列为病脑病原体常规检测。Objective To probe the characteristics of pathogens and the diagnosis on the meningitis from picornavirus group. Methods The objects consisted of the patients with viral meningitis and the patients with non-viral meningitis. Picornavirus group and Coxasackie virus （COX）were detected by reverse transcriptase-polymerase chain reaction （RT-PCR） in cerebrospinal fluid. Results The total positive rate of picornavirus group was 34.5% and Coxasackie virus was 19.1% in picornavirus group in the viral meningitis. The non-viral meningitis was not any positive result of the pathogens. Conclusions The picornavirus group particularly COX is the important pathogens,which cause viral meningitis. RT-PCR is a useful tool for the diagnosis of meningitis from picornavirus group.

关 键 词：脑膜炎病毒 脑脊液 肠道小RNA病毒组 实验诊断 

分 类 号：R373.2[医药卫生—病原生物学] R446.14[医药卫生—基础医学]