鱼腥草对氨苄青霉素和乳糖酸红霉素抗菌作用的影响  

Effects of Herba Houttuyniae on the Antibacterial Activity of Ampicillin and Erythromycin Lactobionate

作　　者：熊南燕[1] 曹明耀[1] 王雪玲[1] 姜彩娥[2] 苏县辉[1] 

机构地区：[1]河北工程大学医学院,河北邯郸056002 [2]河北省邯郸市第一医院,056002

出　　处：《时珍国医国药》2007年第6期1303-1304,共2页Lishizhen Medicine and Materia Medica Research

基　　金：河北省中医药管理局资助项目(No.2006106)

摘　　要：目的观察鱼腥草对氨苄青霉素和乳糖酸红霉素兔体内外抗菌作用的影响。方法将健康家兔25只分为5组,每组5只。第1组给予鱼腥草注射液;第2组给予氨苄青霉素;第3组给予氨苄青霉素加鱼腥草注射液;第4组给予乳糖酸红霉素;第5组给予乳糖酸红霉素加鱼腥草注射液。用量:鱼腥草1 ml.kg-1,氨苄青霉素0.15 g.kg-1,乳糖酸红霉素0.05 g.kg-1,连续耳缘静脉注射6 d后心脏取血5 ml,按微生物法测定各组药物抗菌活性。结果鱼腥草在体内外均无抗菌活性,对兔体内氨苄青霉素抗菌活性有明显增强作用(P<0.01),对乳糖酸红霉素抗菌活性无显著影响(P>0.05)。结论鱼腥草与氨苄青霉素联用有协同作用,与乳糖酸红霉素联用可能无相关作用。Objective To survey the effects of herba houttuyniae on the in vivo antibacterial activity of ampicillin and erythromycin lactobionate in rabbits. Methods 25 healthy rabbits were randomly divided into 5 equal groups ,with 5 animals in each. The rabbits of group 1,2,3,4 and 5 were intrevenously given herba houttuyniae （ 1 ml·kg^-1）, ampicillin （0.15 g·kg^-1 ） ,herba houttuyniae （1 ml·kg^-1） and ampicillin （0.15 g·kg^-1） ,erythromycin lactobionate（ 0. 05 g·kg^-1） ,herba houttuyniae （1 ml·kg^-1） and erythromycin lactobionate（ 0. 05 g·kg^-1）, respectively, once daily for 6 consecutive days. 5ml of blood was then taken from the heart of each rabbit and the antibacterial activities of the sera were measured by microbiological methods. Results Herba houttuyniae itself was shown to have little antibacterial activity in vitro and in vivo, but it did very significantly enhance the in vitro antibacterial activity of ampicillin （ P 〈 0.01 ）. However herba houttuyniae had no obvious influenc on the antibacterial activity of erythromycin lactobionate （ P 〉 0. 05 ）. Conclusion Herba houttuyniae in combination with ampicillin , but not with erythromycin lactobionate , shows to have a synergistic antibacterial activity.

关 键 词：鱼腥草 氨苄青霉素 乳糖酸红霉素 短小芽孢杆菌 微生物法 

分 类 号：R285.5[医药卫生—中药学]