高山红景天对对乙酰氨基酚所致小鼠急性肝损伤的保护作用  

The Protective Effect of Rhodiola sachalinesis(A.Bor) against Acute Liver Injury Induced by Acetaminophen(AAP) in Mice

作　　者：戴博 宋妍[2] 王占一[1] 廉丽花[1] 南极星[1] 

机构地区：[1]延边大学药学院,吉林延吉133000 [2]吉林省四平市食品药品检验所,136000

出　　处：《时珍国医国药》2007年第6期1305-1306,共2页Lishizhen Medicine and Materia Medica Research

基　　金：吉林省杰出科技青年资助项目(No.5-28-17)

摘　　要：目的观察高山红景天(Rhodiola sachalinesis A.Bor)对对乙酰氨基酚(Acetaminophen.AAP)所致小鼠急性肝损伤的保护作用。方法用红景天醇提物或红景天水提物1 g/kg给小鼠灌胃1 h后,灌1 g/kg的对乙酰氨基酚,观察小鼠死亡率的变化;提前1 h用不同剂量的红景天醇提物或红景天水提物处理后,再灌0.5 g/kg的对乙酰氨基酚,以血清中天冬氨酸氨基转移酶(AST/GOT),丙氨酸氨基转移酶(ALT/GPT),观察红景天醇提物及红景天水提物对肝损伤的保护作用[1]。结果给小鼠对乙酰氨基酚1 g/kg灌胃组,24 h后可致80%小鼠死亡;提前1 h用红景天醇提物及红景天水提物灌胃其死亡率可分别下降至30%和20%,而且能不同程度降低血清中AST,ALT的含量,与水飞蓟素无明显差别。结论红景天醇提物及红景天水提物对对乙酰氨基酚所致小鼠急性肝损伤有一定保护作用。Objective To investigate the protective effect of Rhodiola sachalinensis（A. Bor） agaigt acute liver injury in mice induced by Acetaminophen（AAP） . Methods Administered the mice with ! g/kg ethanol or water extraction of Rhodiola sachalinensis, 1 h later, administered the mice with 1 g/kg ace taminophen （AAP）, then observe the death rate. Administered the mice with different doses of ethanol or water extract of Rhodiola sachalinensis , 1 h later, administered the mice with the 0.5 g/kg Acetaminophen（AAP）, then determinea the aspartate aminotransferase （AST） and alanine aminotransferase （ALT）. Results 80% of the group administered with 1 g/kg acetaminophen（AAP） were dead 24 h later, and death rate of the group that were administered with Rhodiola sachalinensis ethanol extraction or Rhodiola sachalinensis water extraction 1 h in advance declined to 30% and 20%, meanwhile the serum enzymes of AST, ALT were reduced, with the same effect as Silymarin. Conclusion Rhodiola sachalinensis（ A. Bor） have certain protective effect against liver injury caused by acetaminophen（AAP）.

关 键 词：高山红景天 对乙酰氨基酚 水飞蓟素 肝损伤 

分 类 号：R285.5[医药卫生—中药学]