复方银杏叶片的急性毒性实验研究  

Experimental Study on Acute Toxicity of Compound Ginkgo biloba Tablets in Mice

作　　者：潘洪平[1] 危华玲[1] 陈英[1] 钟正贤 陈学芬 李燕婧 路玫[1] 

机构地区：[1]广西壮族自治区人民医院,广西南宁530021 [2]广西壮族自治区中医药研究所,广西南宁530022

出　　处：《时珍国医国药》2007年第6期1325-1325,共1页Lishizhen Medicine and Materia Medica Research

基　　金：广西壮族自治区科学基金项目(No.0342003-1)

摘　　要：目的观察复方银杏叶片的急性毒性反应。方法复方银杏叶片以最大浓度及最大给药体积的药液灌胃给药,3次/d。连续观察7 d,记录小鼠毒副反应情况。结果观察7 d后,全部动物健存,小鼠体重平均增长24.82%,未见任何毒性反应。计算得葛根素最大给药量为3339.6 mg/kg体重,相当于成人日用量的2360.1倍。结论提示复方银杏叶片毒性较小。Objective To study the toxic reaction on Compound Ginkgo biloba Tablets in mice. Methods The maximum administration dosage of Compound Ginkgo biloba Tablets were determined by ig administration in mice, three times a day. Its acute toxic reactions were observed for 7 days. Results All mice were survive, and no toxic reaction was shown during the observed period. The average rate of its increasing weight was 24.82 percent. The maximum administration dosage was 3 339.6 mg of puerarin given to mice per kilogram, equivalent to men＇s daily administration dosage by 2360.1 times. Conclusion Compound Ginkgo biloba Tablets is safe for oral administration.

关 键 词：复方银杏叶片 小鼠 急性毒性 

分 类 号：R285.5[医药卫生—中药学]