大黄治疗慢性肾功能衰竭有效成分研究  

Study on the Chemical Constituent of Rhubarb in the Treatment of Chronic Renal Failure

作　　者：翁涛[1] 潘源虎 游菲[2] 

机构地区：[1]武汉生物工程学院,湖北武汉430415 [2]湖北中医学院药学院,湖北武汉430065

出　　处：《时珍国医国药》2007年第6期1427-1428,共2页Lishizhen Medicine and Materia Medica Research

摘　　要：目的对药用大黄治疗慢性肾功能衰竭的化学成分进行研究。方法应用色谱和光谱技术提取分离和鉴定大黄中化学成分(-)-ep igallocatech in-3-o-gallate(EGCG),并通过口服给予对肾切除致肾衰鼠模型治疗,观察各组动物尿素氮和血肌酐含量。结果EGCG能减低肾衰鼠模型血中尿素氮和血清肌酐水平、降低肾小球膜损伤指数,且与药剂量呈一定量-效关系。结论药用大黄中化学成分EGCG能使肾的组织结构和生理功能接近正常。Objective To study the chemical constituent of rhubarb in the treatment of chronic renal failure. Methods Chromatographic and spectral technologies were used to extract , separate and elucidate the chemical constituent EGCG, Treat the kidney in the mouse model through giving orally, observes each group of animal urea nitrogen and the serum myo-anhydride content. Results The level of urea nitrogen in the blood and serum myo-anhydride decrease. EGCG reducd the renal glomerulus＇s membrane damage index. Conclusion The chemical constituent EGCG of rhubarb can protect and repair the kidney organic function .

关 键 词：大黄 肾衰竭 化学成分 

分 类 号：R285.5[医药卫生—中药学]