鼠妇水煎物镇痛作用的实验研究  

Research on the Analgesic Effects of Water Decoction of Armadillidiunm vulgare in Mice

作　　者：苏正兴[1] 田晓乐[1] 赵凌志[1] 孟庆繁[1] 滕利荣[1] 

机构地区：[1]吉林大学生命科学学院,吉林长春130012

出　　处：《时珍国医国药》2007年第6期1429-1430,共2页Lishizhen Medicine and Materia Medica Research

摘　　要：目的观察鼠妇水煎物的镇痛作用。方法通过小鼠扭体法致痛、热板法致痛、大鼠甩尾法热刺激致痛实验对鼠妇水煎物进行镇痛活性研究。结果鼠妇水煎物（蛋白含量）90,180,360 mg.kg-1灌胃（ig）对醋酸引起的小鼠扭体反应有明显的抑制作用,抑制率为32.00%-58.15%;灌胃给药后30 min和45 min明显提高小鼠热板痛阈（P〈0.01,P〈0.05）,镇痛效果随给药量的增加呈剂量依赖关系。结论鼠妇水煎物对多种疼痛模型均具有明显的抑制作用并呈剂量依赖关系。Objective To study the analgesic effects of water decoction of Armadillidium vulgate in mice. Methods The analgesic effects of water decoction from Armadillidium vulgare in mice were studied in mice and rats using writhing reaction , hot -plate nocieeptive test and tail flick test. Results The analgesic experiment showed that protein of water decoction from Armadillidium vulgre at the dose of 90,180,360 mg·kg^-1 had significant inhibition to writhing response （ P 〈 0.01, P 〈 0.05 ） induced by acetic -acid. The inhibitory rate was from 32.00% to 58＇. 15%. The pain threshold in mice with the hot - plate procedure increased obviously after being taken water decoction from Armadillidium vulgate for 30 min and 45 min （ P 〈 0.01, P 〈 0.05 ）. The three groups with different doasges could obviously increase the pain threshold in imee. The pain threshold in rats procedure increased obviously after being taken water decoction from Armadillidium vulgate for 60 rain and 90 rain in the tail flick test （ P 〈 0.01 ,P 〈 0.05 ）. The three groups with different dosages could obviously increase the pain threshold. Conclusion The water decoction from Armadillidium vulgate has significant analgesic effect on animal models and shows obviously dose-effeet ralationship.

关 键 词：鼠妇 镇痛 水煎物 

分 类 号：R285.5[医药卫生—中药学]