转化生长因子-β1与纤维连结蛋白在IgA肾病肾小球硬化模型中的表达及肾络宁的干预作用  

Expression of TGF-β1 and FN in Kidney Tissue of IgA Nephropathy Glomerularsclerosis Rats and Effect of "Shenluoning Compound"

作　　者：刘育军[1] 彭文[1] 甄仲[2] 黄文政[3] 朱小棣[3] 

机构地区：[1]上海中医药大学附属普陀医院肾内科,上海200062 [2]中国中医科学院广安门医院,北京100062 [3]天津中医药大学第一附属医院,天津300193

出　　处：《上海中医药大学学报》2007年第3期63-65,共3页Academic Journal of Shanghai University of Traditional Chinese Medicine

基　　金：国家自然科学基金资助项目(30472129)

摘　　要：目的:观察以疏利少阳为治疗原则的肾络宁对IgA肾病肾小球硬化模型的影响。方法:SD大鼠90只随机分为正常组、模型组、苯那普利组、肾炎康复片组、肾络宁组。采用单肾切除后反复尾静脉注射较大剂量葡萄球菌肠毒素B(SEB)的方法,制作接近人类IgA肾病肾小球硬化病变发展过程的大鼠实验动物模型,并观察不同时间节点时,各组转化生长因子-β1(TGF-β1)、纤维连结蛋白(FN)的表达情况。结果:模型组肾小球TGF-β1、FN表达量升高,各治疗组肾小球中TGF-β1、FN表达量下降。与苯那普利、肾炎康复片组比较,肾络宁组在第9周后的治疗效果更为突出。结论:以疏利少阳为治疗原则的肾络宁对防治IgA肾病肾小球硬化有良好的疗效。Objective：To observe the efficacy of ＂Shenluoning Compound＂ on glomerularsclerosis of lgA nephropathy. Methotis： Ninety SD rats were randomly divided into five groups： normal group,model group, benazepril group, ＂Shenyan Kangfu Tablet＂ group, ＂Shenluoning Compound＂ group. IgA nephropathy glomerularsclerosis rat model was established by intravenous injection of a large dosage of staphyloentero-toxin B repeatedly after unilateral nephrectomy. The expressions of transforming growth factor β1 （TGF-β1） and fibronectin （FN）at different times were detected. Results：The levels of TGF-β1 and FN increased in model group, but decreased in the other three treatment groups. Compared with those of benazepril group and ＂Shenyan Kangfu Tablet＂ group, the therapeutic efficacy of ＂Shenluoning Compound＂ group was significantly better after nine-week treatment. Conclusion： ＂Shenlu- oning Compound＂ is effective on glomerularsclerosis of IgA nephropathy.

关 键 词：IGA肾病 肾小球硬化 转化生长因子-Β1 纤维连结蛋白 

分 类 号：R277.5[医药卫生—中医学]