原发性肝癌脾气虚证量化标准的研究  

Study on Quantified Standard of Spleen-Deficiency Syndrome of Primary Liver Cancer

作　　者：侯风刚[1] 赵钢[2] 岳小强[2] 贺宪民[3] 

机构地区：[1]上海市中医医院肿瘤科,上海200071 [2]中国人民解放军第二军医大学长海医院中医科,上海200433 [3]中国人民解放军第二军医大学统计学教研室,上海200433

出　　处：《上海中医药杂志》2007年第6期23-25,共3页Shanghai Journal of Traditional Chinese Medicine

摘　　要：目的建立原发性肝癌脾气虚证量化标准(包括量化诊断标准和程度分级标准)。方法选择457例患者,在流行病学调查的基础上,以脾气虚证辨证参考标准进行辨证,根据相关因素在脾气虚证组和非脾气虚证组中出现状况的差异对相关因素进行赋分,并以此为基础建立量化诊断标准;然后对量化诊断标准进行检验,最后建立程度分级标准。结果原发性肝癌脾气虚证量化诊断标准最低分为34分;量化诊断标准回顾性和前瞻性检验的敏感度、特异度、准确度均在85%以上,阳性似然比分别为9.6和11.33;程度分级标准:轻度34～48分,中度49～62分,重度≥63分。结论本原发性肝癌脾气虚证量化标准的特点是:①较符合原发性肝癌的特点;②统计学方法运用较为严谨;③验证较为严谨;④较符合中医临床实际。Objective To set a quantified standard （including quantified diagnosis standard and classification standard） on spleen-deficiency syndrome of primary liver cancer（PLC）. Methods Identify spleen-deficiency syndrome according to relevant referenced standard on the basis of survey on clinical epidemiology and evaluate its correlative factors on the basis of difference of their appearance between spleen- deficiency syndrome and non-spleen-deficiency syndrome, and then set its quantified diagnosis standard and test it; at last set the classification standard. Results The diagnosis standard of spleen-deficiency syndrome of PLC is 34 points; the Sen, Spe and ACC of the prospective and retrospective examination of it are over 85%. ＋LR of them are respectively 9.6 and 11.3; 34--48 points is classified as low grade, 49-62 points is classified as medium grade,, high grade is 〉~63points. Conclusions The quantified standard on spleen-deficiency syndrome of PLC has its characteristics： （1）accordance with clinical characteristic of PLC; （2） rigorous statistical methods; （3） religious examination; （4） clinical applied value.

关 键 词：原发性肝癌 脾气虚证 量化标准 临床流行病学 

分 类 号：R273[医药卫生—中西医结合] R735.7[医药卫生—中医肿瘤科]