强心汤对大鼠实验性左室肥厚及心肌超微结构的影响  

Effect of Qiangxin Oral Liquid on Experimental Left Ventricular Hypertrophy Induced by Isoproterenol and Ultrastructure in Rats

作　　者：宁晓然[1] 王敬联[1] 王小平[2] 陶杰梅[1] 于春英[3] 

机构地区：[1]河北省人民医院风湿免疫科,河北石家庄市050051 [2]河北省人民医院功能科,河北石家庄市050051 [3]河北省人民医院中医科,河北石家庄市050051

出　　处：《中国康复理论与实践》2007年第6期524-525,共2页Chinese Journal of Rehabilitation Theory and Practice

基　　金：河北省科技厅科研基金(No972761156D)

摘　　要：目的观察中药强心汤对异丙肾上腺素诱导大鼠实验性心肌肥厚的保护作用。方法连续7d异丙肾上腺素皮下注射建立大鼠心肌肥厚模型。30只大鼠随机分为对照组、模型组和治疗组（造模第2天起强心汤灌胃,连续用药12周）。分别于造模后第2周、6周及12周应用高频超声心动图动态检测心脏结构和功能改变;治疗12周后,测量各组大鼠左心室质量指数,观察心肌超微结构。结果治疗组大鼠的收缩末期室间隔厚度、左室后壁厚度、左室内径、左心室质量指数均较模型组下降（P〈0.05-0.01）,左心功能增强,心肌超微结构损伤程度明显减轻。结论强心汤对异丙肾上腺素引起的大鼠实验性心肌肥厚具有一定的改善作用。Objective To observe the protective effect of Qiangxin oral liquid on experimental left ventricular hypertrophy induced by isoproterenol and ultrastructure in rats. Methods Myocardial hypertrophy model of rats were established by injection of isoproterenol （5 mg/kg/d） for 7 days. Thirty rats were divided into the control group, model group and treatment group （treated with Qiangxin oral liquid from second day after myocardial hypertrophy model made and continued for 12 weeks）. Cardiac structure and function were detected in all groups by ultrasonography on 2nd, 6th and 12th week after model made respectively. After 12 weeks, the left ventricular weight/body weight index （LVW/BW） of all animals was tested and myocardial uhrastructure was examined. Results Compared with the model group, the interventricular septal end systolic thickness, left ventricular posterior wall thickness, left ventricular diameter, and left ventricular mass index of the treatment group decreased significantly （P 〈0.05-0.01）, while the damage of myocardial ultrastructrue lightened. Conclusion Qiangxin oral liquid can improve the experimental myocardial hypertrophy of rats induced by isoproterenol.

关 键 词：强心汤 中药 大鼠 心肌肥厚 异丙肾上腺素 

分 类 号：R972[医药卫生—药品]