乙型肝炎病毒表面抗原阳性孕妇血清前S1抗原检测的临床意义  

The clinical significance of serum pre-S1 protein from pregnant women with positive HBsAg

作　　者：周燕[1] 黄湘宁[2] 刘庆蓉[1] 喻华[2] 

机构地区：[1]四川省成都市妇幼保健院检验科,四川成都610031 [2]四川省医学科学院·四川省人民医院检验科,四川成都610072

出　　处：《世界感染杂志》2007年第3期214-216,共3页World Journal of Infection

摘　　要：目的分析乙型肝炎病毒表面抗原（HBsAg）阳性孕妇血清前S1抗原感染状态与胎儿官内感染的关系。方法收集137例HBsAg阳性孕妇的血清与脐血，HBeAg是否阳性分为HBeAg阳性孕妇血清组和HBeAg阴性孕妇血清组，采用ELISA和PCR方法对两组标本进行preS1与HBVDNA检测。结果HBeAg阳性孕妇血清组preS1检出率为88．5％，明显高于HBeAg阴性孕妇血清组34．1％（P〈0．01）；HBeAg阳性孕妇血清组HBVDNA检出率为96．1％，明显高于HBeAg阴性孕妇血清组25．9％（P〈0．01）；HBeAg阳性孕妇脐血HBVDNA检出率为46．2％，明显高于HBeAg阴性孕妇组11．8％（P〈0．01）；preS1在HBVDNA阳性组中的检出率为88．8％，明显高于HBVDNA阴性组23．1％（P〈0．01）。结论育龄妇女血清乙肝病毒preSl的常规检测，有利于乙肝病毒感染的早期诊断与治疗，可作为母婴垂直传播的一项预防措施。Objective To observe the relation between serum pre-S1 infection status in pregnant women with positive HBsAg and intrauterine fetal infective rate, and to discuss its clinical significance. Methods Pre-S1 protein in sera samples from 137 pregnant women with HBV were detected by ELISA. HBV DNA in maternal serum and cord blood were detected with PCR. Results Pre-S 1 in HBeAg position group detection rate is 88.5 %, obviously higher than the HBeAg negative group 34.1% （P〈0.01）; HB V DNA in HBeAg positive group detection rate is 96.1%, obviously higher than the HBeAg negative group 25.9% （P〈0.01）; HBV DNA in HBeAg position group in cord blood detection rate is 46.2%, obviously higher than the HBeAg negative group 11.8% （P〈0.01）; Pre-S 1 in HBV DNA positive group detection rate is 88.8%, obviously higher than the HBV DNA negative group 23.1% （P〈0.01）. Conciusion To routinely examine the Pre-S1 in sera sample of procreative woman, is helpful to diagnose and cure the hepatitis B virus vertical infection. It can be a preventive measure for the intrauterine fetal infection.

关 键 词：孕妇 乙型肝炎病毒 PRES1 HBV DNA 

分 类 号：R373.21[医药卫生—病原生物学]