苍白球损毁术中微电极的位置识别方法  

Method of Localization of Microelectrode in the Globus Pallidus during Pallidotomy for Parkinson's Disease

作　　者：刘新文[1] 王惠南[1] 钱志余[1] 杨天明[2] 顾月清[3] 

机构地区：[1]南京航空航天大学自动化学院生物医学工程系,南京210016 [2]东南大学附属中大医院神经外科,南京210009 [3]中国药科大学生命科学与技术学院,南京210009

出　　处：《生物医学工程学杂志》2007年第3期488-491,共4页Journal of Biomedical Engineering

基　　金：国家自然科学基金资助项目(30371362)

摘　　要：在治疗帕金森病的苍白球损毁外科手术中,微电极在苍白球中的位置只能通过分析微电极测量的细胞放电特征,依靠主观经验判定。我们以临床微电极信号为基础,利用峰峰时间间隔因子,提出了客观定量的识别微电极位置的方法。该方法能有效的识别出沿微电极针道苍白球组织的变化以及针道是否偏离,识别结果与苍白球解剖结构和手术情况相吻合,此方法可用于临床手术导向。Intraoperative analysis of the position of microelectrode in the globus pallidus only depends on experiences and subjective interpretation of microeletrode recording discharge of neurons during pallidotomy for Parkinson＇s disease. In this paper is reported a method for objective localization of microeletrode during neurosurgery. This method uses the factor of interspike interval based on microelectrode recordings. It is effective for identifying the change of the globus pallidal organism along the microelectrode pathway and the departure or deviation of the needle-pathway. The classification is consistent with the anatomic structures and the results of neurosurgery. This method can be used as a guide in pallidotomy.

关 键 词：帕金森病 苍白球 微电极 卡方检验 

分 类 号：R318[医药卫生—生物医学工程]