几类天然凋亡诱导剂的研究进展  

Advance of Study On Apoptosis Inducer of Several Types of Natural Drug

作　　者：宋毅[1] 曾莹[1] 苏兰[1] 张志勇[1] 

机构地区：[1]四川大学华西医院药剂科,成都610041

出　　处：《生物医学工程学杂志》2007年第3期701-704,共4页Journal of Biomedical Engineering

摘　　要：细胞凋亡诱导剂作为治疗肿瘤药物已成为新药研发的热点。我们介绍了近年来蒽醌衍生物、皂苷类、类黄酮及萜类化合物作为细胞诱导剂的研究现状及进展,并对其作用机理进行分析和归纳。凋亡诱导剂有希望开发为安全有效的抗肿瘤药物。Along with the deep-going researches on mechanism of apoptosis, the apoptosis inducers as anticancer drugs have been the hot points of researches for new drugs. In this paper are reviewed a number of related articles on the progress in cell apoptosis inducers including the derivative anthraquinone, saponin, flavonids and terpines. The mechanisms are analyzed and discussed. The researches into the molecular mechanisms of inducer can provide the theoretical basis for discovering new compound, and can find out the apoptosis inducers with high efficiency and low toxicity. There is hope of developing apoptosis inducers into safe and effectual anticancer drugs.

关 键 词：凋亡 诱导剂 分子机理 

分 类 号：R284[医药卫生—中药学]