糖尿病患者急性心肌梗死后炎性因子的变化及其意义  

Change and significance of inflammatory factors in diabetic patients with acute myocardial infarction

作　　者：高竞生[1] 袁磊[1] 郝冰[1] 吴云涛[1] 施继红[1] 高明[1] 邹吉敏[1] 

机构地区：[1]华北煤炭医学院附属开滦医院心内科,河北唐山063000

出　　处：《华北煤炭医学院学报》2007年第4期445-447,共3页Journal of North China Coal Medical College

摘　　要：①目的 探讨糖尿病患者在心肌梗死后炎性因子的变化及其意义.②方法 87例急性心肌梗死患者分为血糖正常组（64例）及糖尿病组（23例）,另选健康对照组（25例）.采用酶联免疫吸附法（ELISA）测定各组患者入院即刻、第24小时、第48小时、第5天,第7天、第14天血清白介素-1β（IL-1β）、白介素-6（IL-6）,白介素-8（IL-8）、肿瘤坏死因子-α（TNF-α）、干扰素-γ（IFN-γ）含量;健康对照组测1次上述各项指标.③结果 与对照组相比,心肌梗死患者的炎性因子浓度于发病2周内明显升高（P＜0.01）,存在动态变化;炎性因子含量除糖尿病组的血清IL-1第24小时～第14天、IL-6第5～14天及IL-8第5～7天数值较血糖正常组有明显升高外（P＜0.05）,其它数值两组无明显差异（P＞0.05）.④结论 炎症参与了急性心肌梗死全过程,在急性心肌梗死早期的炎性反应中糖尿病起到了一定的促进作用,且主要影响白介素系统,而对肿瘤坏死因子及干扰素无明显影响.Objective To investigate the change and significance of inflammatory factors in diabetic patients with acute myocardial infarction（AMI）. Methods According to bloSd glucose, 87 ST- elevation myocardial infarction （STEMI） patients were separated into normal group（ 64 cases） and diabetic group（23 cases）, and 25 cases were chosen as health control group. Plasma levels of Interleukin （IL） - 1β, IL - 6, IL - 8, TNF -αand IFN - Гat the point of pre - hospitalization, 24h, 48 h, 5d, 7 d and 14d were measured with ELISA method. Results Compared with the control group,the levels of inflammatory factors in the AMI patients raised significantly during 2 weeks and showed dynamic change. Compared with normal group, the contents of inflammatory factors of IL - 1 from 24th h to 14th d, IL - 6 from 5th d to 14th d and IL - 8 from 5th d to 7th d in diabetic group raised significantly（ P 〈 0.05）, but others had no difference（ P 〉 0.05）. Conclusions Inflammatory took part in the course of AMI. In the early stage of AM], diabetic accelerated inflammatory reaction and mainly affected the interleukin system, hut had no evidence effects on TNF and IFN.

关 键 词：糖尿病 急性心肌梗死 白介素-1Β 白介素-6 白介素-8 肿瘤坏死因子-Α 干扰素-Γ 

分 类 号：R587.1[医药卫生—内分泌]