中药复方对鸡免疫器官指数及IL-2表达的动态影响  

Effects of Chinese materia medica on the indexes of immune organs and expression of IL-2 in immune organs in chicken

作　　者：王自力[1] 鲁琳[2] 朱晓宇[2] 胡艳欣[1] 刘凤华[2] 许剑琴[1] 

机构地区：[1]中国农业大学动物医学院,北京100094 [2]北京农学院动物科学技术系,北京102206

出　　处：《中国兽医科学》2007年第6期543-546,共4页Chinese Veterinary Science

基　　金：北京市科委攻关项目(Y0705003041631);国家自然科学基金项目(30270977)

摘　　要：将300只1日龄公雏鸡随机分为3组,两组分别给予中药方Ⅰ和方Ⅱ(由石膏、苍术、黄柏、藿香分别按质量比1∶1∶1∶1和0.5∶1∶1∶1比例组成,按体重0.3 mg/kg的剂量饮水),对照组按照常规方法饲养。分别于雏鸡第7、21、35、49日龄时,每组随机抽取5只鸡剖杀,取腔上囊、脾、胸腺测定免疫器官指数和IL-2平均阳性表达率,以探讨中药复方对雏鸡免疫器官指数及其IL-2表达的动态影响。结果显示,随着用药时间的增加,中药方Ⅰ和方Ⅱ可显著(P<0.05)或极显著(P<0.01)提高腔上囊、脾和胸腺等免疫器官指数及其IL-2的平均阳性表达率,方Ⅰ对各免疫器官IL-2阳性表达率的影响最为显著(P<0.05)。证实该中药复方可促进雏鸡细胞免疫水平,增强其非特异性免疫功能,并促进免疫器官的发育。Three hundred 1-day-old male chickens were divided into 3 groups at random. Group Ⅰ was taken orally 0.3 mg of the Chinese medicine Ⅰ , which was made up of powders of Gypsum fibrosum, dried Rhizoma atractylodis roots-and-rhizomes, dried Cortex phellodendribarks, and Herba agastachis rhizomes-and-leaves at the mass ratio of 1 ： 1 ： 1 ： 1, according 1 kg body weight, Group Ⅱ was taken orally 0. 3 mg of chinese medicine Ⅱ , which was composed of the above-mentioned 4 ingredients at the mass ratio of 0. 5 ： 1 ： 1 ： 1,per 1 kg body weight, and the control group was fed normally. On 7-,21-,35- and 49- day-old, 5 chickens of each group were randomly taken to collect the bursa, spleen, thymus organs to detect the indexes of immune organs and IL-2 expression rates. The average IL-2 expression rates and indexes of immune organs were significantly enhanced by the Chinese materia medica （P〈0.05 or 0.01）. The results indicated that the Chinese materia medica could improve level of cellular immunity, enhance nonspecific immunological function and promote growth of the immune organs.

关 键 词：鸡 中药复方 免疫器官指数 白细胞介素-2 

分 类 号：S853.74[农业科学—临床兽医学] S852.4[农业科学—兽医学]