营养素干预对绝经妇女骨质疏松的影响  

Changes of bone mineral density after one-year nutrition supplement in postmenopausal Chinese women

作　　者：黄振武[1] 董杰[1] 龚洁[2] 曾晶[2] 李卫东[1] 杨晓光[1] 

机构地区：[1]中国疾病预防控制中心营养与食品安全所,北京100050 [2]武汉市疾病预防控制中心科研科,湖北武汉430023

出　　处：《中国健康教育》2007年第6期426-427,共2页Chinese Journal of Health Education

基　　金：国家自然科学基金项目(No.30300286)

摘　　要：目的观察血脂正常但骨密度降低的绝经妇女补充钙、维生素D和大豆异黄酮后,机体骨密度和血脂成分的变化。方法2004年4月从武汉郊区绝经妇女中筛选血脂正常伴骨量减少或骨质疏松的绝经妇女60名,随机均分为两干预组,每组30人。一组给予液体钙(含维生素D);一组给予液体钙(含维生素D)和大豆异黄酮,跟踪观察一年。测定每位受试对象骨骼骨密度和血脂成分。结果试验结束后,补钙组和补钙+大豆异黄酮组,全身及股骨颈的骨密度(BMD)都较基线时显著降低(P<0.05),组间变化无显著性差异(P>0.05);而腰椎、大转子BMD与基线相比,略微升高,但尚无统计学差异。补钙和补钙+大豆异黄酮均能显著降低血总胆固醇(P<0.05)。结论对已出现骨量减少的绝经后妇女补钙一年能降低绝经后BMD的丢失速率,但补充大豆异黄酮一年尚未观察到对BMD的保护作用。绝经妇女补充钙和大豆异黄酮补可能干扰机体的血脂代谢。Objective To observe changes of bone mineral density（BMD） and blood lipid components afte one-year supplement of calcium or caldron and soy isoflavone in postmenopausal Chinese with different ER-β genotypes, Methods 90 subjects with normal serum lipid levels, selected from postmenopausal women in Wuhan in April, 2004. Among the, 60 women with bone loss or even osteoporosis were randomly divided into two interventional groups, one calcium （with VD） group, mad theother calcium （with VD） and soy isoflavone group. All of them were taken to measure their BMD and to collect blcods for lipid components, Results Whole body and femur neck BMD were significandy decreased in both Ca group and Ca ＋ soy isoflavone group, but no significant difference of change percent between two groups. There were no significant changes in L2- L4 and trochanter BMD irrespective of treatment. Both of calcium supplementation and calcium plus soy isoflavone supplementation significantly lowered total cholesterol （P 〈 0.05 ）. Conclusion Rational calcium intake and rational soy isoflavone supplement can be used to prevent the loss of bone mineral density in postmenopausal women, but it can affect the metabolism of blood lipid components, more studies should be taken.

关 键 词：绝经妇女 骨密度 血脂成分 

分 类 号：R193[医药卫生—卫生事业管理]