产舒康颗粒质量控制研究  

Quality Control for Chanshukang Granule

作　　者：程立方[1] 崔秀君[2] 

机构地区：[1]山东省中医药研究院,山东济南250014 [2]济南市妇幼保健院,山东济南250001

出　　处：《中国中医药信息杂志》2007年第6期43-44,共2页Chinese Journal of Information on Traditional Chinese Medicine

基　　金：济南市卫生局科技计划项目(WS20011215)

摘　　要：目的探讨产舒康颗粒的质量控制方法。方法采用薄层色谱法进行定性鉴别,采用高效液相色谱法进行含量测定。色谱条件:Kromasil C18(200mm×4.6mm,5μm)色谱柱;流动相为甲醇-2%冰醋酸水溶液(40∶60);检测波长:324nm。结果本品中检出当归、川芎、胎盘、甘草,阿魏酸在0.625～3.750μg范围内线性关系良好,3批产舒康颗粒中阿魏酸含量分别为0.054%、0.037%、0.042%,平均回收率96.2%,RSD=2.37%。结论薄层色谱法可用于本品中4种中药的鉴别,高效液相色谱法简便、灵敏、准确,为控制产舒康颗粒的质量提供了依据。Objective To study the quality control method for Chanshukang granule. Methods TLC and HPLC method were used to identify the Chinese herbal medicines. The determination was carried on HPLC, using Kromasil C18 column （200 mm×4.6 mm, 5 μm）, ethanol-2% glacial acetic acid （40 ： 60） as mobile phase and detected at the wavelength of 324 nm. Results The Chinese herbal medicines, Radix Angelicae Sinensis, Rhizoma Chuanxiong, Placenta Hominis and Radix Glycyrrhizae Preparata, in granules were identified by TLC. The calibration curve was linear in the range of 0.625-3.750 μg for ferulic acid. The contents in three batches were 0.054%, 0.037%, 0.042% respectively. The average recovery was 96.2% and RSD=2.37%. Conclusion The TLC method can be used for the quality control of four herbal medicines in the granule. The HPLC method is simple, sensitive, accurate and provides a certain evidence for controUing the quality of Chanshukang Granule.

关 键 词：阿魏酸 产舒康颗粒 薄层色谱法 高效液相色谱法 质量标准 

分 类 号：R284.1[医药卫生—中药学]