感染负荷与冠状动脉粥样硬化病变的相关性  

Relationship of infection burden and coronary atherosclerosis

作　　者：金卫国 袁彪[1] 贾恩志[1] 王巍[1] 

机构地区：[1]南京医科大学第一附属医院心胸外科,210029

出　　处：《江苏医药》2007年第6期541-543,共3页Jiangsu Medical Journal

基　　金：国家自然科学基金(30400173)

摘　　要：目的探讨感染负荷与冠状动脉粥样硬化及病变程度的相关性。方法冠脉造影患者87例,冠脉造影检查前抽静脉血,ELISA法检测患者血清巨细胞病毒IgG抗体、幽门螺旋杆菌IgG抗体、肺炎衣原体IgG抗体、单纯带状疱疹病毒IgG抗体和A型流感病毒IgG抗体。根据感染负荷将患者分为三组:1组,感染原≤2种;2组,感染原=3种;3组,感染原≥4种。结果冠状动脉粥样硬化的检出率没有随感染负荷的增加而增加,1、2和3组冠状动脉粥样硬化阳性率分别为84.6%、81.6%和73.9%;感染负荷与动脉粥样硬化阳性率没有相关性(P>0.05)。1、2和3组冠状动脉粥样硬化重度病变率也没有随感染负荷的增加而增加(分别为53.8%、47.3%和43.4%)。结论病原体感染和冠状动脉粥样硬化之间未见明显相关性,冠状动脉粥样硬化阳性率也未随感染负荷的增加而增加。Objective To evaluate the relationship among infection burden, coronary atherosclerosis and the severity of atherosclerosis. Methods Eighty-seven patients underwent coronary angiography in Jiangsu Province People＇ s Hospital in 2004. Seropositivity of cytomegalovirus, helicobacter pylori, chlamydia pneumonia, influenza A virus and herpesviruses-1 were determined by ELISA. According to the infection burden, the patients were divided into group 1 （pathogen≤2）, group 2 （pathogen = 3） and group 3 （pathogen≥4）. Results The ratio of coronary atherosclerosis was neither associated with infection burden significantly （P〉0.05）, nor increased with the increase of pathogen. The prevalence of atherosclerosis was 84.6% ,81.6% and 73.9% for group i, 2 and 3 ,respectively. Neither the severity of atherosclerosis was significantly associated with infection burden nor the degree of the severity was increased with the increasing of infection burden. Conclusion The present study does not suggest that the prevalence of atherosclerosis is associated with infection burden and increased with the increase of infection burden. The severity of atherosclerosis does not increase with infection burden.

关 键 词：动脉粥样硬化 感染 病原体 感染负荷 

分 类 号：R541[医药卫生—心血管疾病]