新生儿缺氧缺血性脑病血清IL-10、NSE变化及临床意义  

The changes and clinical significance of IL-10 and NSE in neonates with hypoxic ischemic encephalopathy

作　　者：蒋红侠 王军[2] 张绍美[2] 

机构地区：[1]徐州市中心医院儿科,221009 [2]徐州医学院附属医院儿科

出　　处：《江苏医药》2007年第6期544-545,共2页Jiangsu Medical Journal

基　　金：江苏省卫生厅医学科技发展基金(Z200308);徐州市科学技术项目(200310)

摘　　要：目的探讨新生儿缺氧缺血性脑病(HIE)血清白细胞介素10(IL-10)及神经元特异性烯醇化酶(NSE)的变化及临床意义。方法选择25例中、重度HIE患儿(HIE组)和15例同期出生的正常足月新生儿(对照组)。HIE组分别于生后1、3、6d,对照组于生后3d内采集外周静脉血,放射免疫法检测血清IL-10及NSE的水平。结果HIE组生后1d血清IL-10及NSE水平显著高于正常对照组(P<0.01);重度HIE组血清IL-10及NSE水平明显高于中度组(P<0.05);HIE组生后6d血清IL-10及NSE水平较生后3d明显下降,但仍高于正常对照组(P<0.01)。结论IL-10及NSE可能参与了HIE的发生发展过程,且其水平与HIE的病情程度密切相关。Objective To evaluate the dynamic changes and clinical significance of interleukin-10 （IL-10） and neuron specific enolase （NSE） in the hewborn infants with hypoxic ischemic encephalopathy（HIE）. Methods Twenty-five infants with HIE（HIE group） and fifteen normal fullterm infants（control group） were recruited in the study. Peripheral venous blood samples on th 3 rd day after birth in control group and on the 1 st, 3 rd and 6 th day after birth in HIE group were collected for detecting serum IL-10 and NSE by RIA. Results The levels of IL-10 and NSE in HIE group on the first day after birth were higher than those in control group（P〈0. 01）. The levels of IL-10 and NSE in the severe HIE group were obviously higher than those in the moderate HIE group （P〈0. 05）. The levels of IL-10 and NSE were lower on the sixth day than those on the third day after birth, but still higher than those in the control group（P〈0. 01）. Conclusion IL-10 and NSE may be involved in the occurrence and development of HIE. The levels of IL-10 and NSE are closely correlated with the severity of HIE.

关 键 词：缺氧缺血性脑病 白细胞介素10 神经元特异性烯醇化酶 新生儿 

分 类 号：R722[医药卫生—儿科]