脑出血灶周脑组织MMP-2和MMP-9的表达  

Study on expression of matrix metalloproteinase - 2 and matrix metalloproteinase - 9 in brain tissue adjacent to hemorrhage after brain hemorrhage in human

作　　者：柯绍发[1] 金笑平[1] 张可浩[1] 王俊兴[1] 胡小铭[1] 张丹红[1] 陈秋月[1] 周元林[1] 

机构地区：[1]浙江省温州医学院附属台州医院,浙江临海317000

出　　处：《中国危重病急救医学》2007年第6期336-339,共4页Chinese Critical Care Medicine

基　　金：浙江省台州市科技计划基金资助项目（051KY18）

摘　　要：目的观察急性脑出血患者灶周脑组织基质金属蛋白酶-2（MMP-2）、MMP-9的表达及其意义。方法选择42例采用外科手术治疗的急性脑出血患者破碎脑组织病理标本;另选30例脑外伤患者出血灶周破损脑组织作为对照。用免疫组化法测定脑组织MMP-2、MMP-9阳性细胞表达情况。结果两组患者脑组织MMP-9和MMP-2阳性细胞表达明显升高。42例急性脑出血早期患者灶周脑组织MMP-9、MMP-2阳性细胞表达分别为39例和37例;而30例脑外伤出血患者脑组织MMP-9、MMP-2阳性细胞表达分别为28例和27例,两组比较差异均无显著性（P均〉0.05）。结论MMP-2和MMP-9参与了人类急性脑出血脑水肿的形成。Objective To investigate the expression and significance of matrix metalloproteinase - 2 （MMP - 2） and MMP - 9 in perihematoma brain tissues after acute brain hemorrhage in human. Methods Forty- two patients with acute brain hemorrhage received surgery, the brain tissues adjacent to hemorrhagic site were obtained during surgery, and positive expressions of MMP - 2 and MMP - 9 were determined with immunohistochemical staining. Brain tissues from 30 patients with cerebral trauma were obtained to serve as controls. Results The positive expressions of MMP - 2 and MMP - 9 in focal brain tissues were significantly elevated in early acute brain hemorrhage. Compared with 28 and 27 cases with MMP - 2 and MMP - 9 positive expression respectively in control group, there were 39 and 37 cases with MMP- 2 and MMP- 9 positive expression respectively in acute brain hemorrhage group. There were no significant differences between two groups （both P〉0.05）. Conclusion MMP - 2 and MMP - 9 might contribute to brain edema formation in the acute intra - cerebral hemorrhage of human.

关 键 词：脑出血 脑组织 基质金属蛋白酶-2 基质金属蛋白酶-9 

分 类 号：R686[医药卫生—骨科学]